Project Grant R01DK138123

This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $1,074,199 to the Albert Einstein College of Medicine to conduct research on the top-down regulation of feeding-related behavior. The research aims to define the connectivity between hypothalamus melanocortin peptide expressing neurons and melanocortin 4 receptor (MC4R)-expressing neurons...

This Project Grant award of $249,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to New York University aims to improve understanding of how hunger and satiety neurons regulate the activity of downstream neurons in the hypothalamus. Specifically, the research will use novel molecular and optical tools to measure and manipulate cyclic AMP (cAMP) signaling in paraventricular hypothalamic neurons that express melanocortin-4 receptors (PVHMC4R), which...

This Project Grant award of $666,229 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of the neuropeptide neurotensin (NTS) in the lateral nucleus accumbens (NACLat) to ventral tegmental area (VTA) pathway and its impact on hedonic feeding behavior. The project aims to study how NTS signaling in this neural pathway modulates reward-related feeding in mice, both on...

The $441,000 Project Grant awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will support research by the CAL Poly Pomona Foundation Inc. to identify a dopamine circuit in the brain that mediates day eating and diet-induced obesity in mice. The 3-year project seeks to genetically and anatomically define a subpopulation of dopaminergic neurons in the ventral tegmental...

This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $148,614 to the University of Southern California (USC) for research on "Hippocampal Dopamine Signaling and Food-Related Memory: Implications for Obesity". The award aims to investigate how dopamine signaling in the hippocampus, a brain region associated with memory, may...

This three-year project grant from the Department of Health and Human Services National Institutes of Health provides $3,555,862 to The Trustees of the University of Pennsylvania under the Trans-NIH Research Support program (CFDA 93.310) to study the interactions between the locus coeruleus-norepinephrine system and the dorsolateral prefrontal cortex in flexible decision-making. Specifically, the researchers will train monkeys on a novel task to quantify how learned expectations and new...

This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to elucidate how POMC neurons in the hypothalamus respond to social stimuli and regulate social behaviors during development. The $461,084 award to Yale University, with a period of performance from June 16, 2025 to June 15, 2027, will leverage in vivo two-photon microendoscopy techniques to map the responses of POMC neurons to social cues in...

The University of Washington was awarded a $149,284 Project Grant by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of specific subpopulations of prefrontal cortex pyramidal neurons in regulating drug-seeking behavior. The research aims to elucidate the factors that predispose individuals to addiction and confer vulnerability to relapse, with the goal of advancing understanding of the functional roles of...

This Project Grant award of $546,831.44 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of the melanocortin-3 receptor (MC3R) in neural circuits regulating feeding, stress, and anxiety behaviors. The research aims to elucidate how MC3R neurons and the bed nucleus of the stria terminalis (BST) function as an integration hub for...

This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $125,879 to President and Fellows of Harvard College (doing business as Harvard Medical School) to characterize how hunger and hypothalamic neuron activity modulate exploratory behavior and dopaminergic neural activity in mice. The project aims to study how caloric deprivation affects mouse exploratory behavior and dopamine release in the...