Project Grant R01DK137305

Award Date 8/16/24
Completion Date 6/30/29
Dollars Obligated $1.3M
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Winston-Salem, NC 27157, USA
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This Project Grant award of $340,822 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to determine the molecular and cellular mechanisms by which heparan sulfate controls parathyroid hormone-related protein (PTHrP) signaling via the PTH type 1 receptor (PTHR). The research aims to characterize the binding properties of PTHrP and heparin/heparan sulfate...
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This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research, provides $587,212 to the University of Alabama at Birmingham (UAB) to conduct research on the role of the CDKN1A (P21) gene in polycystic kidney disease (PKD). The goal of the research is to determine how abnormal regulation of the P21 gene, which is involved in cell cycle control and tissue repair, contributes...
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This Federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) totals $1,335,210 and is intended to support research into hydroxyproline dehydrogenase (HYPDH) inhibitors for the treatment of primary hyperoxaluria (PH). The research program, led by Wake Forest University Health Sciences, aims to optimize HYPDH inhibitor compounds through iterative design, synthesis, biochemical/cellular testing, computational modeling, and evaluation in PH mouse models. A sub-award to the University of Alabama at Birmingham will focus on testing the efficacy of the HYPDH inhibitor compounds in reducing oxalate synthesis in PH mouse models. The overall goal is to develop a therapeutic approach that can significantly lower the glyoxylate and oxalate burden in PH2 and PH3 patients, for whom there are currently no available treatments.

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