This federal Project Grant award, valued at $748,625.76, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at the University of California, San Francisco (UCSF) focused on the "Translational Regulation of PGC1alpha and Oxidative Metabolism." The project aims to advance scientific understanding of the mechanisms underlying...
This $1,008,750 Cooperative Agreement award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports a multi-year research project led by the University of California, San Diego (UCSD) to investigate the cellular and molecular mechanisms underlying cardiovascular disease in individuals with type 1 diabetes. The key objectives are to: 1) comprehensively identify cell...
This $578,060 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to study a potential new enhancer region located upstream of the UCP1 gene. The research aims to elucidate the role of this enhancer and associated transcription factors in regulating UCP1 transcription and thermogenesis, with the goal of identifying new targets...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $1,089,491 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the University of California, Los Angeles (UCLA) to develop novel statistical methods, computational algorithms, and software to study individual health trajectories for disease onset and progression using large-scale real-world data sources like electronic medical records and biobanks....
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $338,007 to the University of California, Irvine to conduct research on how dietary factors can influence the epigenetic silencing of transposable elements and impact organismal health. The project aims to leverage Drosophila as a model system to identify dietary factors that...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) totals $399,545 and will support research to investigate the role of the 14-3-3zeta signaling protein in regulating islet function and the crosstalk between pancreatic alpha and beta cells. The research aims to determine how 14-3-3zeta in beta cells impacts alpha cell glucagon-like peptide-1 (GLP-1)...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $136,449 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to The Regents of the University of California, Berkeley. The grant, titled "Evaluating the Role of Human Obesity Genes in Specific Neuronal Populations in vivo by CRISPRi", will fund research to optimize the development of a CRISPR-mediated gene downregulation approach to rapidly...
This Project Grant award of $1,428,186 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research supports research to investigate the role of CYP4F enzymes in regulating N-acyl amino acid signaling in humans. The principal aims are to: 1) biochemically characterize N-acyl amino acids as substrates and inhibitors of CYP4F enzymes, 2) define the functional consequences of N-acyl amino acid...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is providing $248,915 to the University of Maryland, Baltimore to conduct research on the role of epigenetics and cytokines in type 2 diabetes among African-ancestry populations. The key objectives are to: 1) Infer causality in lifestyle-cytokine associations using Mendelian randomization...
This federal Project Grant award of $892,433 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to provide a more detailed understanding of how upstream eicosanoid pathways relate to the development of chronic kidney disease (CKD) and associated cardiovascular risk. The award will fund research to: (i) identify eicosanoid pathways underlying CKD progression and...