Project Grant R01DE035736
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $634,041 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective May 1, 2026, through April 30, 2031. The award funds a comprehensive five-year research initiative investigating the RNA degradosome of Streptococcus mutans, the primary bacterial species associated with dental caries risk. The...
- Federal Grant Award Summary Oregon Health & Science University received a $121,667 Project Grant from the National Institute of Dental and Craniofacial Research under the Oral Diseases and Disorders Research program (CFDA 93.121), effective April 1, 2026, through March 31, 2028. This award funds the synthesis, characterization, and validation of novel granular hydrogel platforms for the theranostic (simultaneous therapeutic and diagnostic) management of periodontitis, an oral inflammatory...
- Federal Project Grant Award Summary Oregon Health & Science University (OHSU) received a $1.39M Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded July 1, 2025, with completion targeted for March 31, 2030. This grant funds the development and validation of an organ-on-a-chip model replicating the tumor-bone microenvironment interface to advance understanding of oral squamous...
- Federal Grant Award Summary Oregon Health & Science University received $597,807 in Project Grant funding from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121) to establish a novel 13C-labeled oral bacterial metabolite reference library for studying dental caries. The award, effective August 19, 2025, with completion targeted for July 31, 2027, supports the development of a comprehensive metabolite...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Oregon State University a $422,665 Project Grant on June 17, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop an integrated dental plaque bioanalytical platform for point-of-care diagnostics of oral diseases. The research addresses the significant financial burden of dental caries by creating a quantitative electrochemical biosensing platform capable...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $426,250 to the University of Kansas Medical Center Research Institute, Inc. on August 14, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support basic research on pathogenic mechanisms in Streptococcus sanguinis. The two-year project, concluding August 13, 2027, will characterize two endopeptidases (SEPM homologs) encoded by this oral bacterium that can...
- Federal Project Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded $540,629 to the University of Massachusetts Lowell on August 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research investigating human oral host-pathogen interactions and dysbiosis modulation. The project, scheduled for completion by August 14, 2027, focuses on developing and validating an immunocompetent three-dimensional (3D) in vitro model...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded Cleveland Clinic Lerner College of Medicine of Case Western Reserve University a $568,759 Project Grant effective May 1, 2026, through April 30, 2031, under the Oral Diseases and Disorders Research program (CFDA 93.121). This research initiative focuses on elucidating the pathogenic mechanisms underlying periodontitis through investigation of microbial synergy and immune subversion. The project...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded the Regents of the University of Minnesota a Project Grant of $649,046 under the Oral Diseases and Disorders Research program (CFDA 93.121) for a research initiative spanning June 1, 2026 through February 28, 2031. The University of Minnesota will conduct fundamental research investigating the molecular mechanisms by which Streptococcus gordonii, a pioneer bacterial colonizer in dental plaque...
- Federal Grant Award Summary Oregon Health & Science University received a $1.24 million Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded June 13, 2025, with completion targeted for June 12, 2027. The project focuses on developing short-wave infrared (SWIR) fluorophores to enhance intraoperative visualization of buried nerves during head and neck cancer surgery. Current...
Oregon Health & Science University (OHSU) received a $524,669 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), effective June 1, 2026, with a completion date of February 28, 2031. The research project, titled "Exploring Streptococcus sanguinis Extracellular Vesicles as Regulators of Gingival Homeostasis and Periodontal Defense," will advance fundamental knowledge of oral bacterial commensalism and host-microbial interactions through investigator-initiated basic and translational research. The project will deliver research products examining how extracellular membrane vesicles (EMVs) released by the oral commensal bacterium Streptococcus sanguinis regulate immune responses, prevent pathogen-induced cell death, and maintain epithelial barrier integrity. Across three research aims, the project will assess how environmental conditions influence EMV production in clinical bacterial isolates, investigate EMV-mediated host cellular interactions and immune signaling mechanisms, and evaluate EMV protective functions using both cell culture and three-dimensional tissue models. The research will generate scientific findings and methodologies supporting development of novel EMV-based therapeutic strategies to enhance oral health outcomes.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $524.7k | 6/2/26 |