Project Grant R01DE035453
- The National Institute of Dental and Craniofacial Research awarded Cincinnati Children's Hospital Medical Center a project grant of $605,123 on June 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the regulation of palate development and innervation in the context of cleft palate pathology. The research addresses velopharyngeal insufficiency, a functional deficit affecting 20 to 40 percent of children who undergo surgical repair for cleft palate....
- The National Institute of Dental and Craniofacial Research awarded the Stowers Institute For Medical Research $371,250 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the pathogenesis, phenotypic variation, and prevention of craniofacial anomalies. The project examines how genetic and environmental factors interact to produce craniofacial birth defects—conditions such as cleft lip and palate, micrognathia, and craniosynostosis that account...
- The National Institute of Dental and Craniofacial Research, part of the Department of Health and Human Services National Institutes of Health, awarded $315,000 to the University of California, Los Angeles on July 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate bone morphogenetic protein (BMP)-dependent mechanisms underlying mandibular outgrowth and to resolve molecular pathways disrupted in micrognathia, a congenital anomaly affecting mandibular...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $675,063 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research deciphering the conserved grammar of craniofacial enhancer function. The recipient will use the funding to investigate how mutations in gene regulatory elements (enhancers) lead to congenital craniofacial anomalies. The research employs two complementary approaches:...
- The National Institute of Dental and Craniofacial Research awarded the University of New Mexico $305,000 under the Oral Diseases and Disorders Research program (CFDA 93.121) on June 5, 2026. The award funds research into the mechanisms by which PRDM3 and PRDM16 chromatin modifiers control craniofacial cartilage development. The research uses genetic mouse models, in vitro cell culture systems, and molecular tools to test whether precise levels of these paralogs fine-tune Wnt/β-catenin...
- The National Institute of Dental and Craniofacial Research awarded the University of North Texas $142,235 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the relationship between tongue positioning and velopharyngeal insufficiency in individuals with velopharyngeal dysfunction secondary to cleft palate with or without cleft lip. The research addresses the persistent challenge that behavioral interventions to reduce hypernasality—a...
- The National Institute of Dental and Craniofacial Research awarded the University of New Hampshire $299,950 on August 19, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop a functional smoothed deep learning approach combining deep neural networks and functional data analysis techniques for analyzing high-dimensional genetic data associated with orofacial clefts and predicting disease risk. The research will build and validate a functional smoothed deep...
- The National Institute of Dental and Craniofacial Research awarded the University of Southern California $481,739 on September 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop three-dimensional organoid models representing the stepwise neoplastic evolution of head and neck squamous cell carcinoma. The recipient institution will create organoids directly from normal human oral tissues, patient-derived leukoplakia samples, and head and neck squamous cell...
- Federal Grant Award Summary The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $315,000 Project Grant to the University of California, Los Angeles (UCLA) on July 15, 2025, under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant funds a two-year research initiative investigating the distinct roles of neural crest cell populations in cranial suture development and disease, with a completion date of July 14, 2027. The research addresses the...
- The National Institute of Dental and Craniofacial Research awarded the University of California, Los Angeles $449,886 on March 1, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to support research on the regulation of early mandibular morphogenesis by the homeobox protein MSX1. The research addresses craniofacial anomalies, which are among the most common congenital conditions. Mutations in the MSX1 gene are associated with tooth agenesis, cleft palate, and...
The National Institute of Dental and Craniofacial Research awarded the University of Southern California $703,242 on August 18, 2026, under the Oral Diseases and Disorders Research program (CFDA 93.121) to investigate the regulatory mechanisms of soft palate morphogenesis and cleft palate malformations. The funded research examines how the trigeminal nerve regulates soft palate development through molecular signaling pathways. The project tests three hypotheses: that trigeminal nerve-derived signaling molecules such as GDF11 control the fate of craniofacial neural crest–derived mesenchymal cells and regulate perimysial cell interactions; that ARL13B functions downstream of trigeminal innervation to direct soft palate development; and that ARID1A controls the fate of mesenchymal cells critical to soft palate muscle development. The work uses animal models with soft palate defects to investigate these mechanisms and their role in preventing cleft palate, a common birth defect that compromises swallowing, respiration, speech, and middle ear ventilation. Performance occurs at the University of Southern California in Los Angeles, California, with a period of performance extending through June 30, 2029. This is a Project Grant, an assistance type supporting investigator-initiated research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $703.2k | 8/19/26 |