This Project Grant award, with ID R56DE033716, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121). The award, totaling $480,840.00, will support research to investigate the role of the Iroquois homeobox 1 (IRX1) gene in regulating epithelial basal cell activity and gingival wound healing. The research aims to: 1) Determine the expression pattern of IRX1 during embryogenesis and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $521,209.45 Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to The Research Foundation For The State University Of New York (RF SUNY) to conduct research on the role of the transcriptional repressor ZEB2 in human neural crest cell formation and craniofacial pathology. The project aims to delineate ZEB2's function in regulating TGF-beta signaling during neural crest cell development and how...
This Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Department of Health and Human Services, will fund research into the genetic basis of human skeletal facial morphology through July 2025. Provided under the Oral Diseases and Disorders Research program (CFDA 93.121), the $936,510 in funding will support two key aims. First, the awardee will enhance current mesh landmarking procedures for craniofacial bone by developing a dense quasi-landmark...
The National Institute of Dental and Craniofacial Research (NIDCR) has awarded a $148,176 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to The Regents of the University of California, Berkeley. The funding will support research to uncover novel gene regulatory networks underlying craniofacial development and specialization in pupfish species. The project aims to leverage the unique evolutionary model of Cyprinodon pupfishes on San Salvador Island to...
This federal Project Grant award of $999,776.00, awarded on Sep 13, 2024 by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to advance oral health equity through integrated research approaches. The goal is to strengthen the scientific basis for innovations in population-level strategies to improve dental care access, utilization, and quality. The research will focus on historically underrepresented...
This $1,849,232.90 Project Grant was awarded by the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research Federal Grant Program (CFDA 93.121), to The General Hospital Corporation (Massachusetts General Hospital) to identify the cellular and molecular identity of genes and pathways defining dental mesenchymal cell differentiation and fate early in tooth development. The goal is to leverage this information to develop potential therapeutics,...
This National Institute of Dental and Craniofacial Research (NIDCR) Project Grant award under the Oral Diseases and Disorders Research program (CFDA 93.121) provides $320,053 to the University of Southern California (USC) to conduct comprehensive research on the craniofacial skeleton and connective tissue development. The 8-year project will utilize advanced techniques in spatial transcriptomics and mouse genetics to identify genes and pathways regulating the assembly of the craniofacial...
This Project Grant award of $155,500 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a comprehensive examination of the oral virome and its interactions with the oral microbiome. The research aims to shed light on the role of viruses in maintaining oral health and contributing to disease, with the goal of illuminating a neglected aspect of the oral microenvironment and potentially...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $2,055,996 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the University of Texas Health Science Center at Houston. The grant, awarded on September 20, 2024, will fund a research program to investigate skeletal stem cell plasticity as a central mechanism in craniofacial bone formation and diseases. The program consists of three main components: 1) Examining the fates and...
This federal Project Grant award, valued at $294,000 and spanning September 2024 to September 2026, was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to understand the mechanisms of craniofacial cartilage differentiation from human neural crest stem cells, with the goal of developing tissue engineering approaches to repair birth defects and injuries to the head and...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), part of the Oral Diseases and Disorders Research program (CFDA 93.121), provides $503,648 to The University of Iowa to support research aimed at determining how interactions between different transcription factor groups drive the specification of oral/dental or skin fates within the mandibular ectoderm. The research will utilize in vivo animal models, explants, and genome-wide assays to fill a critical knowledge gap in understanding epithelial patterning along the dorsal-ventral axis of the mandible. This 5-year project, with a start date of June 13, 2025 and an ultimate completion date of March 31, 2030, will contribute to improving oral and craniofacial health by advancing the scientific community's knowledge of the genetic programs responsible for developing oral, dental, and skin lineages.