This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $505,056.00 to the University of California, Davis to conduct research on the association between inflammatory tissue environment and Kaposi's Sarcoma-associated Herpesvirus (KSHV) replication. The research aims to understand how KSHV utilizes host cell "trained immunity" functions by inducing...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $1,337,014 over approximately 5 years starting September 1, 2024 to investigate the mechanisms by which Kaposi's Sarcoma-Associated Herpesvirus (KSHV) manipulates cellular metabolism to facilitate viral replication and tumor growth. The key research objectives are to: 1) Determine how KSHV's viral cyclin protein...
This $306,000 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support research to determine the role of Macrophage Migration Inhibitory Factor (MIF) signaling in Kaposi's Sarcoma-associated Herpesvirus (KSHV) pathogenesis and oncogenesis. The research aims to: 1) Determine the mechanisms of MIF signaling activation in KSHV-positive tumor cells, and 2) Develop MIF-targeted...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), provides $583,289 to the University of Arkansas for Medical Sciences to conduct research on the epigenetic regulation of Kaposi's sarcoma-associated herpesvirus (KSHV) latency. The research aims to advance understanding of how KSHV, which causes several AIDS-defining malignancies including Kaposi's sarcoma, can...
This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $601,309 to the University of Florida to conduct research on understanding viral mechanisms that could inform oncolytic therapies for Epstein-Barr virus (EBV)-associated lymphomas in people living with HIV. The key focus of the research is to identify core upstream mechanisms that disrupt silencing of the EBV gene...
This Project Grant award of $155,500 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will support a comprehensive examination of the oral virome and its interactions with the oral microbiome. The research aims to shed light on the role of viruses in maintaining oral health and contributing to disease, with the goal of illuminating a neglected aspect of the oral microenvironment and potentially...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a Project Grant (CFDA 93.121 - Oral Diseases and Disorders Research) to the University of Arizona in the amount of $118,763 for the period of September 1, 2024 to August 31, 2026. The grant will support Dr. Robert Jackson's research focused on assessing the role of human papillomavirus type 16 (HPV16) in transforming versus productive infections in oral epithelial tissues. The research aims to characterize the viral...
This federal Project Grant award in the amount of $469,830.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121). The grant aims to identify oral bacterial species with anti-cancer properties and evaluate their potential for preventing or treating oral squamous cell carcinoma (OSCC). Specifically, the study will assess the effects of Streptococcus mitis and Haemophilus parainfluenzae on OSCC...
This Project Grant award, valued at $470,279.00 and awarded by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), supports research on the impact of bacterial oxidative stress responses on the ecology and pathogenicity of oral streptococci. The key goals are to identify and characterize the mechanisms by which oral streptococci, including the health-associated Streptococcus sanguinis and the caries-associated...
This federal Project Grant award of $429,000.00 was provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research (CFDA 93.121) program. The grant supports research to determine the functional roles and mechanisms of the human microbiome and metabolome in the pathogenesis of oral squamous cell carcinoma (OSCC), a prevalent and lethal form of head and neck cancer. The research aims to 1) define OSCC-associated metagenomic and...