The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $644,970 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to the University of Arizona. The grant will fund research over a 5-year period from July 1, 2025 to June 30, 2030 to investigate the role of immune-epithelial interactions in restoring salivary gland function after radiation therapy for head and neck cancer. The research aims to develop a kinetic model of the metabolic phenotype...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $1,493,635 to Sinopia Biosciences Inc. to develop a novel oral compound for treating radiation-induced oral mucositis. The project aims to characterize a selectively-inhibiting compound that demonstrated compelling results in preclinical studies, with the goal of advancing it towards clinical trials. Oral mucositis is a...
This $598,332 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, will support research to investigate the role of the truncated TrkB isoform (TrkBT1) in oral cancer pain. The primary awardee, the University of Texas Health Science Center at San Antonio (UTHSCSA), will conduct studies to examine how TrkBT1 expressed in trigeminal sensory neurons and oral squamous cell carcinoma (OSCC)...
This federal Project Grant award, provided by the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to improve understanding of oral cancer pain mechanisms. The $162,743 award will support research to develop and validate assays for measuring pressure and stretch sensitivity in oral cancer, as well as leveraging genetically engineered mice to study the role of the TRPV4 ion channel in Schwann cells and...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $714,711 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to the Icahn School of Medicine at Mount Sinai. The 5-year grant, which commenced on July 1, 2025, aims to investigate mechanisms that can specifically protect or regenerate salivary glands without benefiting cancer growth following radiation therapy. The research team developed a scalable gene targeting system to screen over...
The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $808,264 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) federal grant program to The Medical University of South Carolina. The grant aims to elucidate the mechanisms underlying filopodia-mediated intracellular uptake of a cell-penetrating peptide (RD3AD) complex carrying small interfering RNAs (siRNAs), and to determine its ability to target and deliver siRNAs to migrating/invading oral...
This federal Project Grant award of $274,100.00 from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), aims to advance understanding of pain signaling and drug delivery for treating oral cancer pain. The key objectives are to: Determine the impact of oral cancer on the trafficking and signaling of the protease-activated receptor 2 (PAR2) in trigeminal neurons. This will involve investigating changes in PAR2...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), provides $306,200.00 to The Catholic University of America (CUA) to conduct research on molecular mechanisms of damage and repair in an oral mucosa chip. The key objectives of this 2-year project are to: 1) Determine the effects of chemotherapy drugs and fractionated radiotherapy on cell layer morphology, reactive oxygen,...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), totals $499,105 and will support research to develop novel microRNA-based therapeutics to enhance bone regeneration and suppress tumor growth in oral cancer patients undergoing radiation therapy. The key goals are to determine the functions of microRNA-200c in promoting mandibular bone regeneration under radiation conditions and...
This Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), is providing $409,960.00 to Texas A&M University System Health Science Center to develop a human salivary gland-on-a-chip model. The goal is to create a platform that can faithfully replicate normal salivary gland function as well as model the effects of radiation-induced damage, in order to improve drug development efforts...