Project Grant R01DC022232

Award Date 12/1/24
Completion Date 11/30/29
Dollars Obligated $1.4M
Federal Grant Program
93.173
Assistance Type
Project Grant
Place of Performance
California, USA
Similar Awards
This federal Project Grant award of $713,170.00 from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, is funding the development and validation of a Multimodality Micro-Optical Coherence Tomography (MM-MOCT) technology. The MM-MOCT system will provide high-resolution, cross-sectional imaging of the cellular microstructure and metabolic activity of the human cochlea, which is...
The National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program, awarded a $767,494 Project Grant to the University of Miami to develop human inner ear organoid platforms for studying and treating hearing and balance disorders. The key objectives of this 5-year project are to: 1) Establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded the University of Southern California (USC) a $456,500 Project Grant (CFDA 93.173) to develop a novel diagnostic test for sensory hearing loss. The "Gain-Sensitive Cochlear Microphonics" (GCM) test aims to assess the functional state and site of damage within the cochlear amplifier, which is crucial for hearing sensitivity and range. The proposed research will validate the GCM test in mice by comparing...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders (CFDA 93.173) program, provides $1,386,518 to The Johns Hopkins University to examine whether novel video-oculography (VOG) measures of the vestibulo-ocular reflex (VOR) can be used as valid markers of functional outcome following vestibular loss. The research aims to assess semicircular canal function using the...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal grant program "Research Related to Deafness and Communication Disorders" (CFDA 93.173), provides $610,725 to the University of Pittsburgh to conduct research on physiological mechanisms contributing to challenges in speech understanding among individuals with sensorineural hearing loss. The key objectives of the 5-year research program are to: 1) characterize...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $154,568 Project Grant (CFDA 93.173 - Research Related to Deafness and Communication Disorders) to the University of Southern California (USC) to conduct research on "Human Cochlear Masking and Suppression Measured Using Dynamic Stimuli." The award period runs from December 31, 2024 to June 30, 2025. Through this grant, USC will perform research to investigate solutions to problems relevant to...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $102,324 Project Grant under the Research Related to Deafness and Communication Disorders (CFDA 93.173) program to The Medical University of South Carolina (MUSC). The funding supports a research project investigating the role of Dectin-1 expressing macrophages/microglia in age-related auditory nerve degeneration and demyelination. The project aims to define age-dependent changes in Dectin-1 expressing...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $533,978 to the University of Arizona to conduct research on the genomic and epigenomic landscape of otosclerosis. Otosclerosis is an age-related bone disorder affecting the otic capsule that can lead to hearing loss. The research aims to uncover the molecular basis of otosclerosis by...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $415,743 to the Oregon Health & Science University (OHSU) to investigate the origins and roles of macrophages in the development, homeostasis, and repair of the tympanic membrane (eardrum). The project aims to characterize the embryonic source, diversity, and postnatal dynamics of...
This $144,328 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) will fund two key research objectives at Emory University: A randomized controlled trial to test an intervention aimed at increasing participation in ototoxicity monitoring for head and neck cancer patients, particularly those living far from the research center or with advanced disease. The...

This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under CFDA Program 93.173 "Research Related to Deafness and Communication Disorders", provides $1,403,696.00 to the University of Southern California (USC) to conduct research on using optical coherence tomography (OCT) imaging to visualize the fluid compartments of the human inner ear.

The key goals of the project are to: 1) characterize the normal endolymph-to-perilymph ratio in control subjects with normal cochlear function, 2) compare the endolymph-to-perilymph ratio in subjects with Meniere's disease and vestibular schwannoma, and 3) validate the use of OCT for human inner ear imaging and support its use as an outcome measure for clinical trials of new treatments for Meniere's disease. This 5-year project, starting on December 1, 2024, aims to improve understanding of the underlying pathophysiology of sudden sensorineural hearing loss and related inner ear disorders.

Generated 7/15/25, 3:43 AM