This Project Grant award, with a total funding amount of $194,400.00, was provided by the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders federal grant program (CFDA 93.173). The award aims to investigate the causal mechanisms underlying a specific subtype of Meniere's disease, designated MDHP, which has been observed to have a high co-incidence with X-linked hypophosphatemia (XLH), a rare phosphate...
This federal Project Grant award for $176,180, provided by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), will support research to investigate the neurobiological mechanisms underlying emotional responses to acute psychological stress. The primary objectives are to use non-invasive neuromodulation techniques, such as continuous theta burst stimulation (cTBS), to examine the causal role of the dorsal anterior cingulate cortex (dACC)...
This Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $715,662 to The Trustees of the University of Pennsylvania to investigate the epigenetic mechanisms underlying stress vulnerability and the pathogenic links between stress and the increased risk of psychiatric disorders. The research will employ a combination of genetic, genomic, molecular, and behavioral approaches to better understand how chronic...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $459,250 to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH), to investigate the impact of stress and resilience on the longitudinal trajectories of Alzheimer's disease (AD) pathology and cognitive function. The 2-year project aims to elucidate the mechanisms by which stress confers increased risk for AD, with the goal of...
The University of Tennessee has been awarded a 2-year, $153,000 Project Grant (R03MH134181) from the National Institute of Mental Health (CFDA 93.242 - Mental Health Research Grants) to investigate the role of gonadal steroid hormones in neural circuits underlying stress vulnerability. The project will use a Syrian hamster model to examine how androgen receptor (AR) and estrogen receptor alpha (ERa) expression in the medial amygdala and bed nucleus of the stria terminalis contribute to...
The Washington University in St. Louis, Office of Sponsored Research Services Division, received a $2,133,060 Project Grant award from the National Institute on Aging under the Aging Research program (CFDA 93.866). The grant will support research to investigate the sex-dependent effects of stress on the accumulation of amyloid-beta (Aβ) and tau proteins, which are hallmarks of Alzheimer's disease pathology. The study aims to elucidate the signaling pathways that mediate the differential...
This Project Grant award, funded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242), aims to investigate the neural basis underlying the impact of stress on sleep. The $588,018 grant, awarded on September 18, 2024, will be used by the University of Pennsylvania to: Determine the role of noradrenergic neurons in the locus coeruleus and corticotropin-releasing hormone neurons in the paraventricular nucleus in causing stress-induced...
This $1,122,846 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will fund research to investigate the role of hippocampal HCN channels in mediating sex-dependent behavioral responses to social stress and individual differences in social avoidance. The grant, awarded to Augusta University Research Institute, Inc. (doing business as Georgia Health Sciences), will enable the research team to test the hypotheses...
This federal Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), provides $344,589 to Bryn Mawr College to investigate the mechanism by which orexins contribute to sex differences in cognitive flexibility after stress. The research aims to: 1) Use a novel orexin sensor and fiber photometry to examine real-time orexin binding in the orbitofrontal cortex and understand how orexins lead to sex-specific cognitive...
This federal Project Grant award under the Research and Training in Complementary and Integrative Health program (CFDA 93.213), funded by the National Center for Complementary and Integrative Health (NCCIH), is focused on investigating the role of blunted mechanosensation of the heart and gut as a potential mediator of cardiometabolic and affective disorders associated with chronic social stress. The $682,570 award to the Georgia State University Research Foundation Inc. will support a 5-year...