This $1,145,674 federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), part of the National Institutes of Health (NIH), will fund research at Case Western Reserve University to investigate the role of TMC proteins in hair cell mechanotransduction in zebrafish. Specifically, the project aims to determine if TMCs contribute differently to zebrafish hearing, the role of TMCs in hair cell mechanotransduction and lateral line-mediated...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), provides $674,021 to the Massachusetts Eye and Ear Infirmary to advance the development of an implantable microphone technology for totally-implantable cochlear implants (TICI). The project aims to refine and test a novel implantable microphone design called the UMIC, which senses motion of...
This $194,400 Project Grant awarded by the National Institute on Deafness and Other Communication Disorders (NIDCD) under CFDA 93.173 - Research Related to Deafness and Communication Disorders, will support research by the Massachusetts Eye and Ear Infirmary to investigate the role of perineuronal nets (PNNs) and microglia in the dysfunction of parvalbumin-positive interneurons (PVIs) that contributes to hyperacusis and other suprathreshold hearing disorders following sensorineural hearing loss....
This $623,777 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders Program (CFDA 93.173), supports research focused on understanding the role of the immune system and inflammation in hearing loss. The primary awardee, The Washington University, will investigate how viral infections like cytomegalovirus (CMV) impact the development of the blood-labyrinth barrier in the inner ear,...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the federal Research Related to Deafness and Communication Disorders program (CFDA 93.173), will provide $415,743 to Oregon Health & Science University (OHSU) from February 1, 2025 to January 31, 2030. The award will fund research to investigate the role of macrophages (immune cells) in the development, homeostasis, and repair of the tympanic membrane (eardrum). The project...
This federal Project Grant award from the National Institute on Deafness and Other Communication Disorders (CFDA 93.173 - Research Related to Deafness and Communication Disorders) provides $767,494 to the University of Miami to develop human inner ear organoid platforms for research into hearing loss and vestibular disorders. The key objectives are to: 1) Establish and optimize human induced pluripotent stem cell-derived 3D inner ear organoid systems from patients with genetic hearing loss,...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), will fund the development of a cell-type-specific gene therapy approach for TOMT-linked congenital hearing loss. The $305,628 award to Echogenesis Therapeutics Inc. aims to establish the efficacy of their AAV-based, hair-cell-specific gene therapy in restoring hearing in TOMT mutant mice. The key...
The National Institute on Deafness and Other Communication Disorders (NIDCD) awarded a $599,219 Project Grant (CFDA 93.173 - Research Related to Deafness and Communication Disorders) to the Massachusetts Eye and Ear Infirmary in Boston, MA. The grant will fund research to investigate the molecular mechanisms underlying the functional diversity of type I spiral ganglion neurons (SGNs) in the cochlea, which play a crucial role in encoding sound intensity. The research aims to characterize the...
This Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD) under the Research Related to Deafness and Communication Disorders program (CFDA 93.173) provides $673,048.00 to Case Western Reserve University to conduct research on the role of mitochondrial calcium regulation in noise-induced hearing loss. The key objectives of the research are to: 1) Determine the initial changes in function and morphology of cochlear hair cells following acoustic...
This $676,533 Project Grant award from the National Institute on Deafness and Other Communication Disorders (NIDCD), under the Research Related to Deafness and Communication Disorders program (CFDA 93.173), supports research to elucidate the genetic underpinnings of adult-onset hearing loss. The principal investigator at the University of Pennsylvania will leverage genome sequencing and mouse models to identify genomic targets of the ZFP719 gene and determine how its misregulation impacts...