Project Grant R01DC021445
- This $180,497 federal Project Grant awarded by the National Institute of Neurological Disorders and Stroke (NINDS) on August 15, 2023 will support research at Oregon Health & Science University (OHSU) to investigate the circuit architecture and dynamics of the insular cortex and its role in motivational behaviors. The key objectives of the project are to: 1) use machine learning-based algorithms to comprehensively identify functional subdivisions, neuronal types, and cell-specific...
- The National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases awarded a $152,205 Project Grant to The Regents of the University of California San Francisco under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds research to investigate how vagal sensory neurons regulate autonomic responses to achieve metabolic homeostasis, and how downstream neuronal circuits in the nucleus tractus solitarius integrate...
- This federal Project Grant award of $427,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research at Williams College to study the role of the parasubthalamic nucleus (PSTN) in the central regulation of feeding behavior. The key objectives of the funded research are to: 1) determine the sources of incoming projections to PSTN subpopulations, 2) investigate how orexigenic and...
- This Project Grant award from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants program (CFDA 93.242), aims to investigate altered exploration strategies and associated neural circuitry in adolescent bulimia nervosa (BN). The $176,960 grant, awarded on May 1, 2025, will be used to recruit cohorts of early, middle, and late adolescent girls with BN and matched controls to complete a bandit task during fMRI scanning. This will help elucidate the neural...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under CFDA Program 93.242 - Mental Health Research Grants provides $874,625 to the University of California, San Diego (UCSD) to study avoidance learning and its relationship to eating disorder symptoms in anorexia nervosa and bulimia nervosa. The research aims to identify neural and behavioral processes that drive eating disorder symptomatology, with a focus on differentiating between active and passive...
- Federal Grant Award Summary The University of California, San Francisco (UCSF) received a $2.56 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 1, 2025, with a completion date of August 31, 2029. This four-year research initiative investigates the neurobiological mechanisms by which animals learn to associate flavors with...
- This $3,399,600 Project Grant award from the National Institutes of Health (NIH) Office of the Director, under the Trans-NIH Research Support program (CFDA 93.310), supports research by the Max Planck Florida Institute for Neuroscience to identify neuronal ensembles that encode interoception - the body's internal state sensing critical for homeostasis and behaviors. The goal is to develop a new molecular profiling technique called SNAP-TRAP that simultaneously characterizes neuronal activity and...
- The National Science Foundation (NSF) Division of Behavioral and Cognitive Sciences awarded a $800,000 Project Grant to the California Institute of Technology (Caltech) to support research on "Neuronal Substrates Underlying the Construction of Value in Humans". This 3-year grant, which commenced on October 1, 2023, aims to investigate how the human brain forms personal preferences and makes value-based decisions. The research will use intracranial recordings in epilepsy patients to...
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the 21st Century Cures Act - Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative (CFDA 93.372), provides $828,335 to the University of Chicago to investigate the roles of inhibitory and disinhibitory neural circuits in the formation, stabilization, and competition of neural assemblies in the cortex. The project aims to experimentally test theoretical...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Ohio State University a $236,250 Project Grant (CFDA 93.847: Diabetes, Digestive, and Kidney Diseases Extramural Research) effective September 15, 2025, with completion targeted for August 31, 2027. This research initiative will investigate nutrient regulation of the enteroendocrine cell (EEC)-vagal network to advance understanding of gut-brain communication mechanisms...
NEURAL MECHANISMS OF INGESTIVE BEHAVIOR - INTEROCEPTION INCLUDES PROCESSES BY WHICH AN ORGANISM SENSES, INTEGRATES, INTERPRETS, AND REGULATES INTERNAL SIGNALS THAT CONTRIBUTE TO PHYSIOLOGICAL PROCESSES SUCH AS EATING. IN THIS CONTEXT, MORE IS KNOWN ABOUT ASCENDING BRAIN PATHWAYS FOR POSTORAL SIGNALS THAN ABOUT DESCENDING PATHWAYS (E.G. CENTRAL REGULATORS) THAT ALTER PROCESSING OF THIS SENSORY INFORMATION. IN FACT, NIH HAS IDENTIFIED OUR LIMITED UNDERSTANDING OF HOW FOREBRAIN CENTRAL REGULATORS MODULATE ASCENDING INTEROCEPTIVE SIGNALS AND ITS IMPACT ON BEHAVIOR AS CRITICAL KNOWLEDGE GAPS. IMPORTANTLY, EATING IS NOT ONLY REGULATED BY POSTORAL SENSORY SIGNALS BUT ALSO BY ORAL SENSORY SIGNALS (E.G. TASTE). DESPITE ITS PUBLIC HEALTH IMPORTANCE, MAJOR GAPS EXIST IN OUR UNDERSTANDING OF HOW CENTRAL REGULATOR NUCLEI INFLUENCE NEURAL CODING OF ASCENDING SENSORY INFORMATION AND ITS IMPACT ON INGESTIVE BEHAVIOR. THIS PROPOSAL SEEKS TO BROADEN OUR KNOWLEDGE OF HOW AN ANATOMICALLY/MOLECULARLY DEFINED CENTRAL REGULATOR PATHWAY CONTRIBUTES TO TASTE CODING AND INGESTIVE BEHAVIOR. WE HAVE IDENTIFIED AMYGDALA (CEA) CELLS THAT EXPRESS GABA AND SOMATOSTATIN (SST) AS A SOURCE OF SEVERAL DISTINCT CENTRAL REGULATOR PATHWAYS. ONE SUCH PATHWAY PROVIDES INPUT TO A REGION OF THE PONS CALLED THE PARABRACHIAL NUCLEUS (PBN - CEA/SST-TO-PBN PATHWAY). THE PBN IS CRITICAL TO PROCESSING ORAL AND POSTORAL SIGNALS THAT STRONGLY INFLUENCE THE FOODSTUFF AN ANIMAL CHOOSES TO INGEST. OUR CENTRAL PREMISE IS THAT THIS CENTRAL REGULATOR PATHWAY MEDIATES, IN PART, THE NEURAL PROCESSING OF INTEROCEPTIVE INFORMATION AND, CONSEQUENTLY, INFLUENCES INGESTIVE BEHAVIOR. WE WILL USE SST-CRE MICE IN CONJUNCTION WITH CRE-DEPENDENT RETROGRADE VIRUSES TO SPECIFICALLY LABEL AND OPTOGENETICALLY MANIPULATE CEA/SST NEURONS. OUR COMPLIMENTARY AIMS WILL EXPAND KNOWLEDGE OF HOW CEA/SST-TO-PBN NEURONS INFLUENCE INGESTIVE BEHAVIOR DRIVEN BY ORAL AND POSTORAL SIGNALS, NEURAL PROCESSING OF TASTE INFORMATION IN THE PBN, AND NEURAL ACTIVITY OF OTHER CEA/SST REGULATOR NEURONS THAT DIFFER IN TERMS OF WHERE THEY PROJECT IN THE BRAINSTEM (I.E. NST VS. PBN).
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $399.9k | 6/13/25 | ||
| Not listed | $381.4k | 6/14/24 | ||
| Not listed | $381.4k | 6/14/24 |