Project Grant R01DA066170
- The National Institute on Drug Abuse awarded Louisiana State University Health Sciences Center New Orleans $723,353 under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2026. The award funds research examining HIV-associated premature aging through cannabinoid-mediated anti-inflammatory mechanisms. The recipient's research team has established an autopsy program studying HIV viral tissue reservoirs and neuropathogenesis in deceased people living with HIV, analyzing...
- The National Institute on Drug Abuse awarded Duke University $731,879 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the impact of cannabis use on the inflammasome in people with HIV compared to HIV-seronegative persons. The research leverages biospecimens from a cohort of clinically and neurologically phenotyped HIV-infected cannabis users and non-users to determine how recreational cannabis use modulates the NLRP3 inflammasome and its effects on...
- The National Institute on Drug Abuse awarded the University of Alabama at Birmingham $1.765 million on April 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how cannabis use impacts T cell phenotype, HIV seeding and persistence in the central nervous system, and neuropathogenesis in people living with HIV. The project, titled "The Impact of Substance Use on the Role of T Cells in HIV CNS Reservoir Seeding, Persistence, and Neuropathogenesis,"...
- The National Institute on Drug Abuse awarded the University of California, San Diego $1,233,586 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate epigenetic and neuroimmune mechanisms underlying cannabis-cannabinoid neuroimmunomodulation in people living with HIV. The recipient will conduct integrated clinical, postmortem, and mechanistic research examining how THC and CBD reshape the neuroimmune axis in people living with HIV through...
- The National Institute on Drug Abuse awarded $229,500 to The Administrators of Tulane Educational Fund (doing business as Tulane University) on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct basic research on protective immune mechanisms against drugs involved in substance use disorders, including fentanyl, cocaine, and nicotine. The research will test whether specific antibody isotypes or locations of antibody-secreting cells provide protection from...
- The National Institute on Drug Abuse awarded the University of California, San Diego $3,001,884 under the Drug Use and Addiction Research Programs (CFDA 93.279) on June 1, 2026, to conduct translational and cross-species studies of cannabis use and HIV effects on mitochondrial homeostasis in brain macrophages. The research combines a clinical observational study with cellular and in vivo preclinical models to determine how cannabis use affects TREM2-mediated changes in mitochondrial function...
- The National Institute on Aging awarded Louisiana State University Health Sciences Center New Orleans $748,679 on August 5, 2026, under the Aging Research program (CFDA 93.866) to conduct an autopsy-based study examining the anti-inflammatory effects of cannabis on Alzheimer's disease-associated neuropathology in people living with HIV. The recipient will analyze full-body autopsy tissues collected from decedents with and without HIV-1 to characterize HIV-1 tissue reservoirs, assess cannabis use...
- The National Institute on Drug Abuse awarded Thomas Jefferson University $723,388 on May 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate mechanisms regulating central nervous system viral load and reservoir in the context of HIV infection and cocaine use comorbidity. The funded research addresses how DNA-dependent protein kinase mediates transcription-coupled repair during HIV transcription in microglia, the major HIV reservoir in the central nervous...
- The National Institute on Drug Abuse awarded the University of California, San Diego $1,387,755 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate mitochondrial oxidative phosphorylation dysregulation in HIV-associated neurocognitive disorder and opioid use disorder, with NAD+ treatment as a potential therapeutic strategy. The research establishes a three-dimensional human assembloid model composed of iPSC-derived neurons, astrocytes, microglia, and...
- The National Institute on Drug Abuse awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $544,256 on May 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds research into the role of microglial ferritinophagy in HIV and cocaine-mediated neuroinflammation. The research addresses HIV-associated neurocognitive disorders (NeuroHIV) that persist in approximately 30–60 percent of people living...
The National Institute on Drug Abuse awarded Tulane University (The Administrators of Tulane Educational Fund) $1,002,979 on September 1, 2026, for exploratory studies of HIV infection and pathogenesis in the context of THC use under the Drug Use and Addiction Research Programs (CFDA 93.279). The research investigates whether cannabinoids can reprogram leukocytes and glial cells to less inflammatory phenotypes, potentially reducing central nervous system seeding and persistence of the HIV reservoir. The study focuses on HIV-associated neuroinflammation, examining how infiltrated inflammatory leukocytes in key brain regions drive neurodegeneration and cognitive decline despite long-term combination antiretroviral therapy, and whether THC's known anti-inflammatory properties could inhibit this inflammation. Work is performed in Covington, Louisiana, with a period of performance from September 1, 2026, through June 30, 2031. The Drug Use and Addiction Research Programs supports basic, clinical, translational, and implementation research to develop new knowledge and approaches for prevention, diagnosis, and treatment of drug use, misuse, addiction, drug overdose, and related health outcomes, including HIV/AIDS.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.0m | 8/19/26 |