Project Grant R01DA066096
- The National Institute on Drug Abuse awarded the University of California, San Diego $3,001,884 under the Drug Use and Addiction Research Programs (CFDA 93.279) on June 1, 2026, to conduct translational and cross-species studies of cannabis use and HIV effects on mitochondrial homeostasis in brain macrophages. The research combines a clinical observational study with cellular and in vivo preclinical models to determine how cannabis use affects TREM2-mediated changes in mitochondrial function...
- The National Institute on Drug Abuse awarded Duke University $731,879 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the impact of cannabis use on the inflammasome in people with HIV compared to HIV-seronegative persons. The research leverages biospecimens from a cohort of clinically and neurologically phenotyped HIV-infected cannabis users and non-users to determine how recreational cannabis use modulates the NLRP3 inflammasome and its effects on...
- The National Institute on Drug Abuse awarded the University of Alabama at Birmingham $1.765 million on April 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how cannabis use impacts T cell phenotype, HIV seeding and persistence in the central nervous system, and neuropathogenesis in people living with HIV. The project, titled "The Impact of Substance Use on the Role of T Cells in HIV CNS Reservoir Seeding, Persistence, and Neuropathogenesis,"...
- The National Institute on Drug Abuse awarded the University of California, San Diego $142,161 on August 19, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research examining the impact of cannabis use on visual functioning and visuospatial neuropsychological performance in cannabis users with and without HIV. The research will examine performance on visuospatial neuropsychological assessments predicted to indicate driving safety in cannabis users stratified...
- The National Institute on Drug Abuse awarded the University of California, San Diego $1,387,755 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate mitochondrial oxidative phosphorylation dysregulation in HIV-associated neurocognitive disorder and opioid use disorder, with NAD+ treatment as a potential therapeutic strategy. The research establishes a three-dimensional human assembloid model composed of iPSC-derived neurons, astrocytes, microglia, and...
- The National Institute on Drug Abuse, part of the Department of Health and Human Services National Institutes of Health, awarded the University of California, San Diego $192,930 in project grant funding on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports mentoring in patient-oriented research on central nervous system dysfunction in individuals with HIV and substance use. The funded activities provide protected time for the principal...
- The National Institute on Drug Abuse awarded the University of California, San Diego $1,468,376 under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2026, to conduct a prospective study characterizing sex-specific cannabinoid and endocannabinoid biomarkers as predictors of neuropsychological, behavioral, and withdrawal outcomes during cannabis abstinence in emerging adults. The research will recruit 220 participants aged 18–25 (balanced by sex, 64 percent with heavy...
- The National Institute on Drug Abuse awarded Tulane University (The Administrators of Tulane Educational Fund) $1,002,979 on September 1, 2026, for exploratory studies of HIV infection and pathogenesis in the context of THC use under the Drug Use and Addiction Research Programs (CFDA 93.279). The research investigates whether cannabinoids can reprogram leukocytes and glial cells to less inflammatory phenotypes, potentially reducing central nervous system seeding and persistence of the HIV...
- The National Institute on Drug Abuse awarded Louisiana State University Health Sciences Center New Orleans $723,353 under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 1, 2026. The award funds research examining HIV-associated premature aging through cannabinoid-mediated anti-inflammatory mechanisms. The recipient's research team has established an autopsy program studying HIV viral tissue reservoirs and neuropathogenesis in deceased people living with HIV, analyzing...
- The National Institute on Drug Abuse awarded the University of California, San Diego $402,874 under the Drug Use and Addiction Research Programs (CFDA 93.279) on August 1, 2026. The recipient will implement ecological mobile health tools to evaluate short-term prospective relationships between neurobiological functioning and cannabis use in healthy adults. The study combines laboratory-based and ecological mobile assessments administered over a four-week home monitoring period. Smartwatches will...
The National Institute on Drug Abuse awarded the University of California, San Diego $1,233,586 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate epigenetic and neuroimmune mechanisms underlying cannabis-cannabinoid neuroimmunomodulation in people living with HIV. The recipient will conduct integrated clinical, postmortem, and mechanistic research examining how THC and CBD reshape the neuroimmune axis in people living with HIV through epigenetic and transcriptional reprogramming of myeloid and T cells. The project will characterize acute effects through a clinical trial and chronic effects through real-world use observation, profiling single-cell epigenomic and transcriptomic states in cerebrospinal fluid and blood immune cells from both people living with HIV and people without HIV. Prior NIDA-funded observational data demonstrated that cannabis use in virally suppressed people living with HIV correlates with reduced cerebrospinal fluid and plasma inflammatory markers, decreased blood-brain barrier permeability, and reduced monocyte chemoattractant protein-1, with levels in daily cannabis users approximating those in people without HIV. Preliminary single-cell neuroimmune profiling revealed cannabis users exhibited markedly reduced expression of type I interferon-stimulated genes across myeloid and T cell populations, key mediators of chronic neuroinflammation in HIV. Performance occurs at La Jolla, California. The period of performance runs from September 1, 2026, through June 30, 2031. The assistance type is a Project Grant.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $1.2m | 8/24/26 |