Project Grant R01DA065635
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded the Regents of the University of Minnesota a $423,500 Project Grant effective April 1, 2026, through March 31, 2028. This award supports research investigating the therapeutic potential of M5 receptor targeting to mitigate stress-induced increases in drug reward vulnerability. The project examines how chronic stress disrupts muscarinic M5 receptor...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $234,094 to the Regents of the University of Minnesota on June 13, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support fundamental neuroscience research investigating cocaine-induced neuroplasticity. The project, titled "Elucidating the Mechanisms and Relevance of Cocaine-Induced Plasticity of Inhibitory G Protein Signaling in the Prelimbic Cortex," will be conducted at...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Michigan $172,144 through the Drug Use and Addiction Research Programs (CFDA 93.279) to support research on optimizing chemical- and light-dependent protein switches for controlling opioid peptide activity with temporal control. The grant, awarded on June 26, 2025, funds research designed to advance understanding of mu opioid receptor (MOR) mechanisms and their role in pain...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $367,986 to the University of Maryland, Baltimore on June 12, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research examining the impact of perinatal fentanyl exposure on dopamine neuron circuitry and behavior. This project grant, with a completion date of December 11, 2027, funds basic neuroscience research investigating how in-utero exposure to fentanyl—a highly potent...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $386,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 15, 2025, with completion scheduled for August 31, 2027. This R21 exploratory grant funds fundamental neuroscience research investigating the neurobehavioral consequences of fentanyl overdose and their relationship to relapse risk in individuals with opioid use...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $197,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through August 31, 2027. The award supports development and validation of an in vivo Massively Parallel Reporter Assay (MPRA) methodology to characterize the functional role of cis-regulatory elements and genetic variants associated with substance use disorders. Specifically, the...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Minnesota a $600,580 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective August 1, 2025, through July 31, 2028. The University of Minnesota will develop and deliver a three-week summer workshop designed to train graduate-level students and junior researchers in reproducible research methodologies for brain imaging genomics analysis. The workshop...
- Federal Grant Award Summary The University of Florida's Division of Sponsored Research received a $190,625 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) for a two-year project period commencing September 1, 2025 and concluding August 31, 2027. The grant supports research to identify and characterize molecular markers of neuronal inhibition in the nucleus accumbens following opioid exposure. The project aims to...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a Project Grant totaling $787,594 under the Drug Use and Addiction Research Programs (CFDA 93.279) for research on the cortical mechanisms of opioid reinforcement. The award, effective September 1, 2025, through May 31, 2030, supports a comprehensive research program investigating the molecular, cellular, and circuit-based mechanisms underlying opioid use disorder...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded Icahn School of Medicine at Mount Sinai a $159,615 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2025, for research extending through June 30, 2027. This K99/R00 award supports a research initiative titled "Predicting Craving and Relapse Using Neurobehavioral Markers of Goals and Habits in Opioid Use Disorder." The project delivers longitudinal neurobehavioral...
The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Minnesota a $673,724 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective May 1, 2026, through February 28, 2031. This research initiative will investigate how opioid exposure modifies nucleus accumbens microcircuits, with the ultimate goal of reversing or preventing maladaptive neuroplastic changes associated with opioid addiction. The project focuses on low-threshold spiking interneurons (LTSIs), specialized neurons expressing somatostatin and neuronal nitric oxide synthase that serve as critical regulators of drug-seeking behavior and nucleus accumbens output. The research deliverables will consist of empirical findings examining interactions between LTSIs and other nucleus accumbens cell types during the acquisition, extinction, and reinstatement phases of intravenous fentanyl self-administration in mice. The principal research activities will employ advanced neuroscience techniques including optogenetic stimulation, electrophysiological recording in acute brain slices, transgenic mouse models, and intersectional genetic strategies to selectively manipulate mu opioid receptor (MOR) signaling within LTSI populations. These scientific investigations will generate foundational knowledge regarding opioid-induced neural adaptations and identify potential therapeutic targets for preventing fentanyl-seeking behavior reinstatement, contributing to NIDA's research priorities in substance use disorder treatment and prevention.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $673.7k | 4/28/26 |