Project Grant R01DA065298
- The National Institute on Drug Abuse awarded The University of Iowa $537,469 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate carbonic anhydrase 4 as a non-opioid therapeutic target for reversing opioid-induced neurobiological changes underlying relapse and drug-seeking behavior. The research employs a multidisciplinary approach in mice to delineate synaptic, circuit, and network-level mechanisms through which carbonic anhydrase 4 disruption and...
- The National Institute on Drug Abuse awarded the University of California, San Diego $165,669 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to identify behavioral and neural markers of opioid withdrawal-induced risk-taking and their relationship with relapse vulnerability. The research establishes and validates a translatable rodent model of opioid withdrawal to explore cognitive factors linked to relapse. The project uses the rat Iowa Gambling Task to...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA), under its Drug Use and Addiction Research Programs (CFDA 93.279), awarded $877,500 to the University of California, San Diego for a two-year project (July 15, 2025 through June 30, 2027) investigating neurobiological mechanisms underlying cocaine use disorder (CUD) susceptibility. The project employs a novel polygenic prediction methodology called RATTACA to identify pre-existing cellular differences in gabaergic and...
- The National Institute on Drug Abuse awarded Vanderbilt University $236,664 on September 25, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how cocaine self-administration differentially alters neural encoding of drug and non-drug reinforcers in the nucleus accumbens. The research uses cellular-resolution imaging with microendoscopes to record single-cell neural activity in awake and behaving animals in response to both cocaine and sucrose, tracking how...
- The National Institute on Drug Abuse awarded Northwestern University $722,218 on March 1, 2026, for research on the effects of developmental environment on dopamine circuit structure and function under the Drug Use and Addiction Research Programs (CFDA 93.279). The project runs through December 31, 2030, with place of performance in Chicago, Illinois. The research investigates how early life stress produces long-lasting impacts on dopamine circuit function and development into adulthood, using...
- The National Institute on Drug Abuse awarded The University of Chicago a $1.010 million cooperative agreement on April 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how social experiences during adolescence affect neurodevelopmental mechanisms regulating addiction susceptibility. The research integrates behavioral assays, computational tools, drug self-administration studies, and single-cell genomic analyses in rats across adolescence and adulthood....
- The National Institute on Drug Abuse awarded Boston Children's Hospital $800,131 on May 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the functions and mechanisms of a molecularly defined prefrontal cortex neuron subtype in drug addiction. The research focuses on identifying and characterizing POU3F1-expressing layer 5 neurons in the prefrontal cortex and their role in regulating cocaine-seeking behavior. The work employs single-cell RNA sequencing...
- The National Institute on Drug Abuse awarded $675,247 to Texas A&M University System Health Science Center on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate how cocaine exposure disrupts cognitive flexibility through cholinergic dysregulation in the dorsomedial striatum. The project examines cocaine-induced alterations in medium spiny neurons and cholinergic interneurons, focusing on three specific aims. Aim 1 defines how enhanced inhibition...
- The National Institute on Drug Abuse awarded Icahn School of Medicine at Mount Sinai $720,691 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to design and develop blood-brain barrier-crossing conjugates that enable delivery of antisense oligonucleotides to the brain for treating cocaine use disorder. The project addresses the lack of FDA-approved medications for cocaine use disorder by leveraging recent advances in antisense oligonucleotide technologies to...
- The National Institute on Drug Abuse awarded The Medical University of South Carolina $211,680 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research investigating neurobiological mechanisms underlying reward-cue associations and relapse-like behavior in substance use disorders. The project, NPAS4+ Neuronal Ensembles: Mechanisms of Reward-Cue Associations and Relapse-Like Behavior, examines how neuronal activity in the nucleus accumbens...
The National Institute on Drug Abuse awarded The University of Iowa $612,115 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate neural systems mediating competing motivations for cocaine seeking in individuals with cocaine use disorder. The research uses rat models to probe corticolimbic circuitry and decision-making under competing motivations. The investigator developed a novel behavioral paradigm in which rats undergo trial-based cocaine self-administration with discriminative stimuli indicating whether lever presses will produce cocaine or footshock. Competition trials present both stimuli and consequences simultaneously, enabling the team to examine neural circuits that mediate decisions to engage in cocaine seeking despite negative consequences. The work focuses on the insular cortex's role in drug craving and decision making under risk, building on prior findings that identified this region as critical in the extinction of cocaine-seeking behavior. Performance occurs in Iowa City, Iowa. The award period runs through May 31, 2031. This is a Project Grant assistance type supporting basic research in substance use prevention, diagnosis, and treatment as part of NIDA's broader research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $612.1k | 7/30/26 |