Project Grant R21DA062929
- Federal Project Grant Award Summary Virginia Commonwealth University (VCU) received a $931,500 project grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, with completion anticipated May 31, 2030. The award supports research development of novel mu opioid receptor (MOR) selective bitopic ligands designed to counteract the effects of synthetic opioids such as fentanyl and other novel synthetic opioids...
- Federal Project Grant Award Summary Virginia Commonwealth University received a $1,406,056 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective July 1, 2025, through March 31, 2029. The award supports secondary data analyses investigating vulnerability to substance use transitions and trajectories in adolescents participating in the Adolescent Brain Cognitive Development (ABCD) Study, a longitudinal national...
- Federal Grant Award Summary Virginia Commonwealth University received a $1.86M Project Grant award from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279) on July 15, 2025, with completion targeted for April 30, 2030. This mechanistic research study investigates the role of the orexin system and insomnia within a buprenorphine opioid use disorder (OUD) treatment sample. The research aims to identify neurobiological mechanisms linking poor OUD...
- Federal Project Grant Award Summary Boston University Medical Campus received a $109,076 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded January 9, 2026, with completion targeted for July 31, 2029. The grant supports basic neuroscience research investigating the role of G alpha Z (GAZ) protein in mediating behavioral responses to opioids. The research aims to elucidate how GAZ signaling in specific brain...
- Federal Grant Award Summary American University received a $476,496 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning August 15, 2025, and concluding July 31, 2028. The grant funds fundamental neuroscience research investigating opioid signaling mechanisms in reward-guided decision-making within the rat prefrontal cortex, specifically the prelimbic area. The research employs a two-alternative forced choice...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Johns Hopkins University a $466,363 Project Grant effective June 1, 2026 through April 30, 2031 under the Drug Use and Addiction Research Programs (CFDA 93.279). This award supports fundamental research to characterize and exploit allosteric crosstalk among pain receptors, specifically examining how endogenous neuromodulators such as endocannabinoids and oxytocin allosterically modulate mu-opioid receptor (MOR)...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $1,980,870 Project Grant to The Washington University, Office of Sponsored Research Services, effective August 1, 2025, through April 30, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). The award funds preclinical research to advance the analgesic potential of novel peripherally-restricted cannabinoid type 1 receptor (CB1R) ligands for pain management. The research addresses a critical gap...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Washington University a $1,964,283 Project Grant effective August 15, 2025, through April 30, 2030, under the Drug Use and Addiction Research Programs (CFDA 93.279). This research initiative will investigate mesolimbic dopaminergic adaptations underlying altered reward sensitivity in chronic neuropathic pain (CNP), with research to be conducted at the university's St. Louis, Missouri facility. The project...
- Federal Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded the University of Massachusetts Lowell a $1,009,623 Project Grant (Drug Use and Addiction Research Programs, CFDA 93.279) effective June 1, 2026, through May 31, 2028. This award funds the discovery and development of novel, non-opioid analgesics derived from marine microbial natural products to address chronic pain, identified as the nation's leading public health crisis affecting over 25 million...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a Project Grant of $163,350 under the Drug Use and Addiction Research Programs (CFDA 93.279) to The University of Texas Health Science Center at San Antonio, effective February 15, 2026 through January 31, 2028. This award funds research investigating the molecular regulation of the kappa opioid receptor (KOR) by 14-3-3 gamma, a scaffolding protein that modulates opioid receptor signaling in peripheral neurons. The...
Virginia Commonwealth University received a $426,938 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) awarded on June 15, 2026, with a completion date of May 31, 2028. The award supports research investigating whether Astrocyte Elevated Gene-1 (AEG-1), a novel transcriptional regulator, mediates an anti-opioid system that could improve opioid analgesic safety and efficacy. The research addresses the critical gap in pain management by exploring mechanisms to reduce opioid tolerance and adverse effects that contribute to the opioid epidemic. The funded research encompasses two primary objectives: (1) identifying molecular and cellular mechanisms by which AEG-1 deletion reverses morphine antinociceptive tolerance through peripheral neuronal sensory neuroinflammatory pathways, and (2) evaluating the impact of AEG-1 deletion on morphine reward and dependence. The research deliverables will include mechanistic findings that could facilitate the design of AEG-1-inhibitory therapeutic strategies to enhance both the safety and efficacy of opioid analgesic pharmacotherapy, contributing to evidence-based approaches for improved chronic pain management with reduced liability for abuse and dependence.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $426.9k | 6/8/26 |