Project Grant R01DA063633
- Federal Grant Award Summary The National Institute on Drug Abuse awarded a Project Grant of $673,724 to the Regents of the University of Minnesota under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on nucleus accumbens microcircuitry regulation by opioid exposure. Beginning May 1, 2026, and concluding February 28, 2031, this research project will investigate how opioid exposure, specifically fentanyl, modifies neural circuits in the nucleus accumbens and develop...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $423,500 Project Grant to the Regents of the University of Minnesota, Office of Sponsored Projects Administration, effective June 1, 2026 through May 31, 2028, under the Drug Use and Addiction Research Programs (CFDA 93.279). This award funds preclinical neuropharmacological research investigating the interactions between xylazine, a 2-adrenergic receptor (2AR) agonist increasingly incorporated into illicit...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA), administering funds through the Drug Use and Addiction Research Programs (CFDA 93.279), awarded $423,500 to the Regents of the University of Minnesota for a two-year research project (April 1, 2026 – March 31, 2028) investigating the therapeutic potential of M5 receptor targeting in stress-induced potentiation of drug reward. The research addresses a critical gap in substance use disorder (SUD) treatment by...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Michigan $172,144 on June 26, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research on optimizing chemical- and light-dependent protein switches for controlling opioid peptide activity with temporal control. This project seeks to advance understanding of mu opioid receptor (MOR) function and mechanisms underlying opioid medication...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $386,500 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), effective September 15, 2025 through August 31, 2027. This R21 exploratory grant funds neuroscience research investigating the relationship between fentanyl overdose (OD), anhedonia (loss of pleasure/reward motivation), and relapse risk in opioid use disorder (OUD). The...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of Michigan a $595,171 Project Grant on May 1, 2026, through the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct fundamental neuroscience research on opioid receptor signaling mechanisms. The grant funds a five-year research project extending through February 28, 2031, investigating how mu opioid receptors (MOR) on medial thalamic neurons mediate pain relief, reward, and...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the University of California, San Diego a $1.39 million Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective March 1, 2026, with completion targeted for December 31, 2030. This grant supports research investigating mitochondrial oxidative phosphorylation dysfunction in the comorbid epidemics of HIV-Associated Neurocognitive Disorders (HAND) and Opioid Use Disorder (OUD) in the...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $116,865 Project Grant to The Washington University on August 3, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of locus coeruleus mu opioid receptors in fentanyl drug seeking. The research project, extending through February 28, 2029, will be conducted at the university's facilities in St. Louis, Missouri, and aims to establish the specific role of the...
- Federal Project Grant Award Summary The University of Alabama at Birmingham received a $894,000 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) effective April 1, 2026, through March 31, 2028. This research award supports two distinct but complementary projects addressing the opioid crisis. The first project integrates individually tailored behavioral activation therapy into a reentry primary care program for...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $197,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through August 31, 2027. The award supports development and validation of an in vivo Massively Parallel Reporter Assay (MPRA) methodology to characterize the functional role of cis-regulatory elements and genetic variants associated with substance use disorders. Specifically, the...
The Regents of the University of Minnesota received a $361,563 Project Grant from the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279), effective June 1, 2026 through March 31, 2031. The award funds research and development of long-acting nanoparticle formulations containing opioid antagonists, mixed agonist-antagonist compounds, and agonists designed to treat synthetic opioid overdose, prevent opioid withdrawal, and mitigate renarcotization risk from fentanyl and fentanyl analogs. The research addresses a critical public health need, as these highly potent synthetic opioids account for over 70% of overdose deaths in the United States. The project deliverables include development and characterization of multiple nanoparticle formulations—specifically antagonist formulations (naloxone, nalmefene, and naltrexone), mixed agonist-antagonist formulations (buprenorphine, nalbuphine, and butorphanol), and an agonist formulation (desmetramadol)—with emphasis on determining effective dosing, evaluating withdrawal symptomatology, and preventing anhedonia. The research aims to extend protective effects against fentanyl-induced respiratory depression for up to 48 hours, representing a significant advancement over currently available treatments and reducing the need for intensive acute medical care and extended patient observation in overdose cases.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $361.6k | 5/26/26 |