Project Grant R01DA062734
- Federal Project Grant Award Summary Tufts University School of Medicine received a $386,500 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) on September 15, 2025, with completion scheduled for August 31, 2027. This R21 exploratory grant funds fundamental neuroscience research investigating the neurobehavioral consequences of fentanyl overdose and their relationship to relapse risk in individuals with opioid use...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded $367,986 to the University of Maryland, Baltimore on June 12, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research examining the impact of perinatal fentanyl exposure on dopamine neuron circuitry and behavior. This project grant, with a completion date of December 11, 2027, funds basic neuroscience research investigating how in-utero exposure to fentanyl—a highly potent...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded UC San Diego a $197,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective September 1, 2025, through August 31, 2027. The award supports development and validation of an in vivo Massively Parallel Reporter Assay (MPRA) methodology to characterize the functional role of cis-regulatory elements and genetic variants associated with substance use disorders. Specifically, the...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded the Regents of the University of Minnesota a $673,724 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) effective May 1, 2026, through February 28, 2031. This research initiative will investigate how opioid exposure modifies nucleus accumbens microcircuits, with the ultimate goal of reversing or preventing maladaptive neuroplastic changes associated with opioid addiction. The project...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Washington University a project grant of $116,865 under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate the role of locus coeruleus mu opioid receptors in fentanyl drug seeking. The award, effective from August 3, 2026, through February 28, 2029, supports research aimed at addressing the growing opioid epidemic by establishing the specific neurobiological mechanisms underlying...
- Federal Grant Award Summary The National Institute on Drug Abuse awarded the University of Cincinnati a Project Grant totaling $1,723,975 on July 15, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct translational research on single-cell opioid and fentanyl responses in the context of HIV infection. The research employs a multi-omics approach combining in vivo and ex vivo studies to evaluate the impact of fentanyl on peripheral blood mononuclear cell (PBMC)...
- Federal Project Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $163,350 Project Grant to The University of Texas Health Science Center at San Antonio on February 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research on the molecular regulation of the kappa opioid receptor (KOR) by 14-3-3 gamma. The project, which runs through January 31, 2028, will deliver fundamental neuroscience research investigating how a conserved...
- Federal Project Grant Award Summary The University of Texas at Austin received a $159,625 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) beginning July 1, 2025, and concluding June 30, 2027. This award supports basic research investigating age and sex differences in reward responding following punishment exposure, with the ultimate objective of establishing whether punishment serves as an effective deterrent for...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded a $195,253 Project Grant to the University of Texas at Austin, effective May 1, 2026 through April 30, 2031, under the Drug Use and Addiction Research Programs (CFDA 93.279). This K01 Research and Training Award supports the adaptation and pilot testing of Mindfulness-Based Relapse Prevention (MBRP) specifically tailored for substance use peer workers (PWs). The project addresses a critical workforce retention gap by...
- Federal Grant Award Summary The National Institute on Drug Abuse (NIDA) awarded The Washington University a $577,531 Project Grant on March 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct a multiomic analysis of brainstem respiratory control regions in fentanyl overdose decedents. The research will generate the first single-nucleus paired RNA sequencing and single-nucleus assay for transposase-accessible chromatin sequencing (multiome) data from the...
FEDERAL PROJECT GRANT AWARD SUMMARY The National Institute on Drug Abuse (NIDA) awarded a $490,179 Project Grant (CFDA 93.279: Drug Use and Addiction Research Programs) to the University of Texas at Austin on May 15, 2026, for research investigating the neurobiological mechanisms mediating fentanyl-induced elevations in risk-taking behavior in rats. The five-year project, concluding February 28, 2031, addresses a critical knowledge gap regarding how synthetic opioids impair decision-making and increase risk-taking during abstinence from opioid use—factors that contribute to relapse in opioid use disorder. The research employs rat models of risk-taking that incorporate both reward and punishment outcomes to identify dysfunction in neural circuits, specifically basolateral amygdala projections to the nucleus accumbens shell and associated cell populations, responsible for fentanyl-induced increases in risk-taking behavior. The project's primary deliverables are fundamental neuroscience findings and experimental data that elucidate the neural mechanisms by which fentanyl impacts risk evaluation and decision-making processes. By identifying these neurobiological pathways, the research aims to establish targets for developing cognitive interventions and therapeutic strategies to mitigate opioids' effects on risk-taking behavior and ultimately reduce relapse rates among individuals with opioid use disorder. This basic translational research supports NIDA's mission to develop new knowledge and approaches for prevention, diagnosis, and treatment of drug use and addiction through mechanistic investigation of addiction-related neural dysfunction.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $490.2k | 5/11/26 |