Project Grant R01DA062618
- The National Institute on Drug Abuse awarded the University of Maryland, Baltimore $1,371,874 under the Drug Use and Addiction Research Programs (CFDA 93.279) on March 15, 2026, to investigate the impact of opioid use disorder on mitochondrial dysfunction among antiretroviral therapy-receiving aging people with HIV. The research addresses a gap in understanding how long-term antiretroviral therapy and opioid use disorder compound inflammaging—a low-grade chronic proinflammatory immune...
- The National Institute on Drug Abuse awarded Johns Hopkins University $198,164 on October 17, 2025, under the Drug Use and Addiction Research Programs (CFDA 93.279) to conduct research examining barriers to medications for opioid use disorder (MOUD) treatment for individuals transitioning from correctional facilities to community settings. The research employs a complex systems approach combining quantitative and qualitative methods. Specific aims include examining the structure and function...
- The National Institute on Drug Abuse awarded the University of Maryland, Baltimore $153,560 under the Drug Use and Addiction Research Programs (CFDA 93.279) on November 30, 2026, as a Project Grant (F32DA066191). The award funds research investigating how mitochondrial regulation influences structural plasticity and cocaine-seeking behavior in ventral hippocampus-nucleus accumbens projection neurons following prolonged abstinence from intravenous cocaine self-administration. The research...
- The National Institute on Drug Abuse awarded the University of Alabama at Birmingham $661,299 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to support research into opioid use disorder mechanisms and potential therapeutic targets. The research, titled "A Novel Cellular and Circuit Target for Opioids," investigates a transcriptionally distinct neuronal population in the nucleus accumbens that expresses high levels of the mu opioid receptor...
- The National Institute on Drug Abuse awarded the University of California, San Diego $165,669 on August 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to identify behavioral and neural markers of opioid withdrawal-induced risk-taking and their relationship with relapse vulnerability. The research establishes and validates a translatable rodent model of opioid withdrawal to explore cognitive factors linked to relapse. The project uses the rat Iowa Gambling Task to...
- The National Institute on Drug Abuse awarded Yale University $659,834 on June 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate cannabinoid receptor type 1 (CB1R) availability in individuals with opioid use disorder. The study uses [11C]OMAR PET imaging to assess CB1R availability in 55 early abstinent individuals with opioid use disorder following inpatient buprenorphine stabilization and 55 matched healthy controls (total N=110). Individuals with...
- The National Institute on Drug Abuse awarded The Johns Hopkins University $466,363 on June 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to characterize allosteric crosstalk among opioid and endogenous neuromodulator receptors. The project uses cryo-electron microscopy to determine high-resolution structures of the mu-opioid receptor in active and inactive states bound to cannabinoids and neuropeptides including oxytocin. The work advances time-resolved cryo-EM...
- The National Institute on Drug Abuse awarded the University of Maryland, College Park $444,801 on September 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to optimize medications for opioid use disorder (MOUD) expansion across Maryland using data-driven implementation strategies. The project constructs a MOUD access index integrating opioid use disorder prevalence, provider capacity, spatial accessibility, and contextual factors to model need for and access to MOUD....
- The National Institute on Drug Abuse awarded the University of Maryland, College Park $152,300 on August 20, 2026, through the Drug Use and Addiction Research Programs (CFDA 93.279), a federal grant program supporting basic, clinical, translational, and implementation research in substance use, addiction, and related health outcomes. The recipient will conduct a project grant examining neural and cognitive mechanisms underlying perseverance and their disruption following juvenile social play...
- The National Institute on Drug Abuse awarded Drexel University $832,132 on March 1, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate novel circuit mechanisms underlying opioid-induced dopamine elevations in the nucleus accumbens, operating beyond the canonical midbrain dopamine neuron pathway. The research explores how oxycodone enhances dopamine signals through local circuits in the nucleus accumbens, specifically examining the role of GABA and cholinergic...
The National Institute on Drug Abuse awarded the University of Maryland, Baltimore $656,916 on August 15, 2026, under the Drug Use and Addiction Research Programs (CFDA 93.279) to investigate insular-amygdala conflict processing mechanisms in opioid use disorder relapse prevention. The project, titled "Insular-Amygdala Conflict Processing After Voluntary Abstinence," examines how the anterior insular cortex (AIC) processes conflicting motivations in individuals with opioid use disorder (OUD). The research systematically contrasts the AIC's role in driving opioid-seeking behavior following forced versus voluntary abstinence, and in the presence and absence of conflict stimuli. The investigator will compare AIC function during negative-valence conflict (induced by electric barriers) and positive-valence conflict (induced by social partner engagement) using projection-selective measurements and manipulations to distinguish the roles of AIC-basolateral amygdala (AIC-BLA) and AIC-central amygdala (AIC-CEA) pathways in opioid-seeking behavior. The work addresses knowledge gaps that currently hinder progress in understanding AIC function in substance use disorder and supports development of new relapse-prevention strategies, given that nearly eighty percent of OUD patients relapse to daily use within a month of abstaining. Performance occurs in Baltimore, Maryland. The award period runs through May 31, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $656.9k | 8/5/26 |