Project Grant R01DA062509
- This Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $233,088 to The Washington University to investigate the role of dorsal raphe nucleus enkephalin neurons in motivational and affective behaviors during chronic pain. The primary goal is to determine how endogenous opioids in the dorsal raphe nucleus contribute to the emotional component of chronic pain states. The research will use dual-color 1-photon endoscopic...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $1,320,580 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Washington University in Missouri. The grant will fund preclinical studies to evaluate the analgesic potential of a novel, peripherally-restricted cannabinoid type 1 receptor (CB1R) agonist called VIP36. The key objectives are to assess VIP36's efficacy in mouse models of post-traumatic headache,...
- This federal Project Grant award of $118,457.00 from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), is funded under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research by Dr. Sylvanus Toikumo at the University of Pennsylvania to characterize the genetic architecture underlying chronic pain and addiction, with the goal of informing the development of non-addictive analgesic medications. The project aims to leverage...
- This federal Project Grant award in the amount of $5,057,591 was provided by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct a comprehensive, prospective observational study with 2,400 emergency department patients seeking care for acute pain. The study aims to: 1) characterize clinically-informed pain phenotypes, 2)...
- This federal Project Grant award of $613,786.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to elucidate the molecular, cellular, and physiological consequences of D1 dopamine receptor (D1DR) signaling from both the plasma membrane and Golgi compartments in primary medium spiny neurons. The research aims to advance understanding of the role of compartmentalized D1DR signaling in the neurobiology...
- This federal Project Grant award of $476,496.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at American University investigating the role of opioid signaling in reward-guided decision-making within the rat prefrontal cortex. The project, led by the Principal Investigator, will utilize intra-cortical pharmacology, computational modeling, and video analysis to examine how cortical opioid receptors...
- This Project Grant award of $153,000.00, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a 6-month longitudinal study examining the relationships between naturalistic cannabis use, pain perception, and functioning (e.g., pain-related disability, physical activity, sleep) in the daily lives of young adults with chronic pain. The study will use an ecological momentary assessment burst design to capture...
- This $173,799 federal Project Grant was awarded by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant was awarded on May 1, 2025 to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania, to support research aimed at revealing, at the cellular and neural circuit levels, how the endogenous opioid system is...
- This federal Project Grant award for $667,349.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) grant program. The award is supporting research conducted by the University of Pennsylvania to investigate the role of endogenous opioid signaling and neural circuits involved in modulating pain perception and placebo analgesia. The research aims to elucidate the...
- This federal Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $226,608.00 to support research on dissecting the mechanisms of dopamine transmission and its roles in reward-related behaviors. The research will investigate how dopamine signaling occurs at the subcellular level and the implications for neuropsychiatric diseases and substance abuse disorders. The grant was awarded to the University of Colorado-Denver on...
This Project Grant award for $668,131 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The purpose of the award is to conduct research on chronic neuropathic pain (CNP) and understand how alterations in dopamine function and reward processing may contribute to the affective symptoms of CNP. The research aims to quantify changes in dopamine release in the nucleus accumbens core across the acute to chronic pain transition, and to characterize the cellular mechanisms underlying dopamine dysfunction in CNP. The awardee, The Washington University, is a leading private research institution with extensive expertise in biomedical sciences and federal research contracts/grants. This 5-year award began on August 15, 2025 and is scheduled for completion by April 30, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $668.1k | 8/7/25 |