Project Grant R01DA062186
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $194,903 to support research led by Dr. Ashish Thakrar at the University of Pennsylvania. The goal is to rigorously develop and evaluate a "loading dose" approach to initiating methadone treatment for hospitalized patients with opioid use disorder who are using the synthetic opioid fentanyl. This research aims to improve outcomes for...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $193,250 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Trustees of Tufts College, doing business as Tufts University School of Medicine in Boston, Massachusetts. The grant, awarded on September 15, 2025, aims to determine whether fentanyl overdose induces an anhedonic phenotype, which in turn increases the risk of relapse in individuals with opioid use...
- The National Institute on Drug Abuse (NIDA) awarded a $861,291 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to New York University (NYU) to conduct a comprehensive evaluation of the impact of New York State's new Mobile Methadone Unit (MMU) program. The project, titled "NY MOVES: Evaluating the Impact of New York's Methadone Outreach Vehicles", aims to assess the reach and effectiveness of the MMU program in improving access to methadone treatment,...
- This $147,486 federal Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) will support a mixed-methods study examining the predictors and outcomes of methadone and buprenorphine receipt during incarceration. The study will analyze a longitudinal database on health service use and outcomes among 4,558 incarcerated individuals who received these medications from 2016-2023 at a unified jail and prison system in the Northeast....
- This federal Project Grant award of $457,701 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to understand the pharmacodynamics of combined methamphetamine and fentanyl use. The primary objectives are to: 1) elucidate the mechanisms underlying polysubstance use disorders involving stimulants and opioids, and 2) investigate the role of the hypocretin/orexin neuropeptide system as a potential target for...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, will evaluate the benefits of a hand-held, automated, personalized oral liquid dispensing system for take-home methadone medication management for patients with opioid use disorder (OUD). The $326,410 award, with a performance period from June 1, 2025 to May 31, 2026, will support a clinical program delivered by Berkshire Biomedical Corporation. The project aims to...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a 5-year Project Grant of $184,706 to the University of North Carolina at Chapel Hill (UNC-CH) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund research to investigate the impact of fentanyl consumption on noradrenergic plasticity in the basolateral amygdala, a key component of the stress response. Specifically, the project will develop a mouse model of...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $192,500 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Wayne State University. The grant supports a 2-year study to measure the effects of gestational fentanyl exposure on offspring in a rodent model. The research aims to determine the impact on morbidity, mortality, developmental milestones, external morphology, blood cholesterol, brain morphology and...
- This Project Grant award of $587,188.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a multi-omics research study on the impact of fentanyl use on cells susceptible to HIV infection. The research aims to evaluate the effects of fentanyl on the single-cell transcriptome and microRNA profiles in various peripheral blood mononuclear cell types, including CD4+ and CD8+ T lymphocytes, monocytes, B lymphocytes, dendritic...
- This Project Grant award of $722,917 from the National Institute on Drug Abuse (NIDA), part of the Department of Health and Human Services, will fund a 5-year study to evaluate a new approach for dispensing methadone to incarcerated individuals with opioid use disorder (OUD) in three state prison systems. The project aims to support widespread implementation of the hospital/clinic designation, which allows carceral facilities to stock and dispense methadone for OUD treatment, by launching a...
The National Institute on Drug Abuse (NIDA) awarded a $915,478 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Brown University to evaluate the effectiveness and safety of different methadone treatment strategies, including dosing and expanded take-home flexibilities, for patients with opioid use disorder in the era of fentanyl. The project aims to address challenges in methadone initiation and maintenance for individuals with a history of fentanyl use, as current treatment protocols were developed based on heroin use populations. The research seeks to provide evidence-based updates to methadone treatment approaches and protocols to improve morbidity, mortality, and quality of life outcomes for this patient population. The project period runs from September 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/3/25 | ||
| Not listed | $915.5k | 8/22/25 |