This $5.37 million project grant from the National Institutes of Health National Institute on Drug Abuse will fund the development of a context-aware digital adherence intervention called SMARTSTEPS to improve pre-exposure prophylaxis (PrEP) adherence among men who have sex with men with substance use disorder. The grant will support two phases. Phase I will inform the specification of an algorithm that utilizes digital phenotyping data from a smartphone app to anticipate non-adherence based...
The National Institute on Drug Abuse (NIDA) awarded a $3,067,394 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The University of Kentucky Research Foundation. The grant, titled "Engaging People Who Use Drugs in Harm Reduction Service Delivery: An Intravention to Reduce Risk of HIV, HCV, Overdose, and Injection-Related Infections in Rural Appalachia," will test a peer-driven approach to address unmet harm reduction needs in two rural Kentucky...
The National Institute of Nursing Research (NINR), under the Nursing Research Federal Grant Program (CFDA 93.361), awarded a $1,606,442 Project Grant to Duke University to conduct a cluster randomized controlled trial of the "Using PREP, Doing It For Ourselves (UPDOS) Protective Styles" intervention. This e-health intervention aims to improve PrEP (pre-exposure prophylaxis) uptake among Black cisgender women in the southern United States, who have been disproportionately affected by...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $1,681,276 to the Research Foundation of the City University of New York (RFCUNY) to conduct research on optimizing long-acting injectable (LAI) pre-exposure prophylaxis (PrEP) strategies for sexual minority men (SMM) who use methamphetamine. The study aims to qualitatively identify modifiable care options for LAI PrEP use through rapid interviews,...
This $677,589 Project Grant award from the National Institutes of Health (NIH) Office of the Director's Trans-NIH Research Support program (CFDA 93.310) supports the development and pilot testing of a novel HIV prevention program targeting women experiencing incarceration. The "FIT for PrEP" (F4P) program aims to link these high-risk women to post-release pre-exposure prophylaxis (PrEP) services and address associated social determinants of health during community re-entry. Key aspects...
This Project Grant award of $606,924, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a 2-year research study entitled "CHAMPION - Combining HIV and Stimulant Prevention and Treatment Interventions Optimized for HIV-Negative MSM." The study aims to evaluate the feasibility, acceptability, and preliminary efficacy of a mobile health intervention package that combines a PrEP adherence app with virtual...
This Project Grant award of $665,225 from the National Institute of Mental Health (NIMH), under the Mental Health Research Grants (CFDA 93.242) program, will fund the "SUUBI4PREP: Improving PrEP Access and Adherence among Adolescent Girls and Young Women in Uganda" project. The project aims to implement a multilevel combination intervention focused on increasing pre-exposure prophylaxis (PrEP) initiation and adherence among adolescent girls and young women living in HIV hotspots in...
The National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $460,432 Project Grant to the Regents of the University of Minnesota to develop and pilot a comprehensive telehealth program at syringe service programs (SSPs) to engage people who inject drugs (PWID) into the HIV care continuum. The key products and services to be delivered include: Conducting formative research to understand determinants of HIV and addiction among...
This $715,041 Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) will support research to understand real-world choices, preferences, and outcomes related to the roll-out of oral and long-acting injectable PrEP (pre-exposure prophylaxis) among women in Malawi. The study, titled "Better Info on Women's PrEP Choices and Outcomes in Malawi", has three specific aims: 1) Evaluate longitudinal patterns of oral...
This Project Grant award, totaling $2,127,639, was provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855). The grant supports a research project to develop a multi-level integrated strategy that combines two evidence-based interventions - "Many Men, Many Voices" (3MV) and "Client-Centered Care Coordination" (C4) - to optimize PrEP adherence and accelerate implementation at scale...
This Project Grant award, totaling $1,953,293, was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The funding supports research to optimize delivery of pre-exposure prophylaxis (PrEP) care for underserved rural people who inject drugs (PWID) in Kentucky.
The study will deploy stepped-care adaptive interventions across three rural syringe service programs to identify optimal pathways for increasing PrEP initiation and persistence. Key intervention components include peer-led strengths-based case management, CDC PrEP education plus text messaging, mobile outreach, and peer transitional case management. The research aims to compare the effectiveness of these adaptive interventions and examine factors predicting PrEP outcomes to inform tailored strategies for PWID subgroups. A sub-award of undisclosed amount was provided to the Knox County Health Department to facilitate study-related activities, including providing private space, an advanced practice nurse clinician to deliver PrEP clinical care, and coordination with the study team.