Project Grant R01DA061799

Award Date 7/1/25
Completion Date 3/31/30
Dollars Obligated $759K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Pennsylvania, USA
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This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,876 to conduct preclinical trials targeting the neuropeptide S (NPS) receptor to mitigate opioid taking and seeking behaviors in animal models. The goals of the project are to demonstrate proof-of-concept that NPS receptor-targeted molecules can reduce oxycodone self-administration and motivation in rats, which could inform the...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,411,145 to Rowan University from September 30, 2024 to July 31, 2029. The project aims to unravel the neurobiological mechanisms by which the GPR83 receptor and its endogenous ligand PEN interact with the mu-opioid receptor (MOR) in the periaqueductal gray region of the brain. This research seeks to determine if targeting the GPR83 pathway can...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,251 to The Trustees of the University of Pennsylvania to develop a novel "released markers of activity" (RMAs) blood-based monitoring system for long-term tracking of neural circuit activity and opioid receptor gene expression changes in mice exposed to opioids. The goal is to better understand the molecular and functional...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
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This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $267,310 to the University of Miami to assess the functional role of calcitonin gene-related peptide (CGRP) expressing neurons within the parabrachial nucleus (CGRPPBN) in opioid reinforcement and to determine the associated gene expression and epigenetic changes. The goal is to explore non-opioid targets to treat opioid use disorder, a...
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This federal Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) provides $759,339 to The Trustees of the University of Pennsylvania to conduct research on the role of central amylin receptors in opioid-mediated behaviors. The key objectives are to:

  1. Comprehensively define the functional roles of cell type-specific ventral tegmental area (VTA) and nucleus accumbens (NAc) amylin receptors in opioid taking and seeking behaviors using viral-mediated methods in transgenic rats.

  2. Determine how amylin pharmacotherapy alters intracellular calcium dynamics in specific VTA and NAc cell types of oxycodone-experienced and drug-naive rats to understand how activation of central amylin receptors modulates midbrain and striatal circuits to suppress opioid taking and seeking.

  3. Characterize the effects of oxycodone alone and in combination with amylin pharmacotherapy on amylin receptor expression and differentially expressed genes in VTA and NAc cell populations using single nuclei transcriptomics.

The goal is to advance a novel framework for developing pharmacotherapies that target central amylin receptor-expressing cells to treat opioid use disorder. The award period is from July 1, 2025 to March 31, 2030.

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