This $562,014 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is funding research on the role of the medial habenula (MHB) and interpeduncular nucleus (IPN) circuits in opioid dependence and withdrawal. The research team at the University of California, San Diego (UCSD) is using molecular, physiological, and behavioral approaches to study how mu-opioid receptor (MOR) signaling in excitatory neurons in...
The National Institute on Drug Abuse (NIDA), through the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $267,310 Project Grant to the Regents of the University of Minnesota to investigate the role of the neuropeptide VGF and its derived peptide TLQP-62 in regulating synaptic plasticity in the nucleus accumbens and their contribution to opioid withdrawal behaviors. The project aims to use electrophysiology, neuroanatomical mapping, and behavioral assays to understand how VGF...
The University of Miami was awarded a $267,310 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant, awarded on September 13, 2024, supports research to assess the functional role of calcitonin gene-related peptide (CGRP) expressing neurons within the parabrachial nucleus (CGRPPBN) in opioid reinforcement and withdrawal. The research aims to determine the gene expression and epigenetic changes associated with...
The National Institute on Drug Abuse (NIDA) awarded a $483,056 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Massachusetts Medical School to conduct research on the mechanisms linking opioid addiction, sleep, and circadian rhythms. The primary goals are to investigate the roles of the circadian transcription factor NPAS2 and dopamine D3 receptor signaling in the nucleus accumbens in controlling opioid craving and relapse behaviors. The...
The National Institute on Drug Abuse (NIDA) awarded a $581,914 project grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the Texas A&M University System Health Science Center. The 5-year grant, effective August 1, 2024, seeks to uncover the biological basis for why sleep apnea patients are more sensitive to opioid-induced respiratory depression (OIRD), which is a leading cause of opioid overdose deaths. The research will investigate how oxytocin neurotransmission from...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $761,711 to Virginia Commonwealth University (VCU) to investigate the role of the orexin system in the intersection of opioid use disorder (OUD) and insomnia. The 5-year study will use the NIDA Phenotyping Battery to examine how pharmacologically antagonizing the orexin system with the FDA-approved drug lemborexant affects symptoms related to...
This Project Grant award of $373,181 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research focused on understanding the role of cholinergic interneurons in the ventral tegmental area that express mu-opioid receptors and their contribution to opioid reward, consumption, and withdrawal behaviors. The project aims to determine whether these interneurons and their mu-opioid receptors participate in opioid-related...
The National Institute on Drug Abuse (NIDA) has awarded a 5-year, $2,185,966 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to the University of Mississippi Medical Center. This grant will support research to investigate the role of orexin (hypocretin) dysregulation in short sleep duration as a predictor of methamphetamine intake in female rhesus monkeys. The project aims to evaluate the hypotheses that: 1) orexin process dysregulation, particularly involving...
This $601,612 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the role of the habenula-interpeduncular nucleus (IPN) circuit in the development of opioid tolerance and withdrawal. The project will use viral approaches, ribosome profiling, and calcium imaging in mice to examine gene expression changes and neuronal activity in the IPN in response to chronic oxycodone exposure. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $340,000.00 to The Washington University in St. Louis, Missouri to conduct research on the role of the locus coeruleus-noradrenergic (LC-NE) system in fentanyl withdrawal and associated negative affective behaviors. The key objectives of this 2-year research project are to: 1) determine whether fentanyl withdrawal selectively modifies the...