This federal Project Grant award of $1,243,350.00, issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the mechanisms underlying sleep disturbances associated with opioid withdrawal. The key objectives of this 5-year project are to: 1) determine how spontaneous withdrawal from chronic morphine administration disrupts the neuronal activity and membrane properties of wake-active noradrenergic...
This $1,594,478 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support a 5-year prospective, observational study of 300 participants initiating treatment with medications for opioid use disorder (MOUD). The key objectives are to: 1) curate a dataset of craving patterns during MOUD using continuous wearable sensor data; 2) model craving trajectories and examine factors associated with opioid use...
This Project Grant award, totaling $1,432,293, was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The funding supports research investigating the mechanistic relationship between circadian rhythms, sleep disturbances, and opioid addiction, with a focus on the role of the transcription factor NPAS2 and dopamine D3 receptor signaling in the nucleus accumbens. The University of Massachusetts Medical School, the primary...
This $1,539,260 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to investigate the role of the kappa opioid receptor (KOR) system in opioid use disorder (OUD). The key products and services to be delivered include: Using [11C]EKAP positron emission tomography (PET) imaging to compare KOR availability in inpatient early abstinent individuals with moderate-to-severe OUD (N=40) versus matched...
This federal Project Grant award of $1,704,286 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to uncover the biological basis for why sleep apnea patients are more sensitive to opioid-induced respiratory depression (OIRD), which is a leading cause of death from opioid overdose. The key objectives are to investigate how deficient oxytocin neurotransmission from the paraventricular nucleus of the hypothalamus (PVH)...
The $858,600 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to identify and validate G protein-coupled receptors (GPCRs) expressed by somatostatin-expressing inhibitory neurons in the prefrontal cortex as potential targets for developing novel treatments for opioid use disorder (OUD). The research aims to take an unbiased transcriptomics approach to identify GPCR transcripts in these...
This federal Project Grant award of $159,711 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research aimed at uncovering the neurophysiological signatures related to acute opioid use within the brain's addiction circuitry. The principal investigator, Dr. Ryu, will leverage a unique opportunity to directly record neural signals from deep brain regions in awake human patients to assess changes in connectivity within...
The National Institute on Drug Abuse (NIDA) awarded a $1,039,420 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to The Medical University of South Carolina (MUSC). The 5-year grant, running from June 1, 2025 to February 28, 2030, will support research aimed at characterizing the transcriptomic profiles and causal functions of specific neuronal ensembles within key brain circuits that govern the facilitation and disinhibition of alcohol and opioid seeking...
This federal Project Grant award, funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the role of orexin (hypocretin) signaling in the ventral tegmental area as a common mediator of sleep disturbances and drug demand during cocaine abstinence. The $1,118,601 grant, awarded on July 15, 2024, with a completion date of May 31, 2029, will support research activities across three key aims: Examining whether the...
This $680,046 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports a 5-year study to examine how social functioning, including social behaviors, social reward, and social connection, changes during opioid use disorder (OUD) treatment and how these factors predict treatment adherence and outcomes. The study will integrate self-reports from 100 patients with OUD and their...
This federal Project Grant award of $1,523,422.00 was issued by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The award will fund a research study to investigate the role of the orexin system at the intersection of opioid use disorder (OUD) and insomnia. The study aims to examine the effects of the dual orexin receptor antagonist lemborexant on sleep, reward, negative emotionality, and metacognition among individuals with OUD receiving buprenorphine treatment. The research will employ the NIDA Phenotyping Battery to deeply phenotype participants and explore intervention responses by sex, behavior, and biopsychosocial variables. The project will be conducted by Virginia Commonwealth University over a 5-year period from September 30, 2024 to July 31, 2029. The findings are expected to advance the understanding of neurofunctional mechanisms underlying OUD treatment response.