Project Grant R01DA061185

Award Date 7/1/25
Completion Date 3/31/30
Dollars Obligated $716K
Federal Grant Program
93.279
Assistance Type
Project Grant
Place of Performance
Seattle, WA 98195, USA
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This Project Grant award of $1,383,618 from the National Institute on Drug Abuse (NIDA) under CFDA Program 93.279 - Drug Use and Addiction Research Programs supports research to investigate the microglia-mediated adverse effects of cannabis (specifically Delta-9-tetrahydrocannabinol or THC) on prefrontal cortex maturation and cognitive function during adolescence. The research aims to: 1) identify the time course of cannabinoid receptor type 1 (CNR1)-mediated molecular and morphological...
The National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $169,580 Project Grant to the University of Maryland, Baltimore to investigate the effects of Delta-9-Tetrahydrocannabinol (THC) exposure during brain development in ferrets. The research aims to examine changes in cannabinoid type-1 receptor (CB1R) expression and function, and the impact on ocular dominance plasticity (ODP) in the primary visual cortex. Key objectives include...
This Project Grant award of $220,340 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research at Washington State University to investigate the role of microglia, a type of immune cell in the brain, as a mechanism underlying the cognitive deficits associated with adolescent cannabis use. The study aims to determine if microglial activation is necessary for the impairments in cognitive flexibility observed in adulthood...
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This federal Project Grant award of $360,100 was provided by the National Institute on Drug Abuse (NIDA), which administers the Drug Use and Addiction Research Programs (CFDA 93.279). The grant supports a research project titled "Socio-Structural Determinants of Cannabis and Derived Psychoactive Cannabis Product Use and Consequences Among Young Adults." The project will investigate the factors influencing the use of cannabis and derived psychoactive cannabis products, such as delta-8...
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This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $716,455.00 to the University of Washington to study the impacts of oral THC consumption during adolescence on adult mouse brain development and behavior.

The key research objectives are to: 1) Determine how long-term adolescent use of THC-gelatin alone or in combination with CBD impacts cannabimimetic responses and natural aversive/reward behaviors in adulthood; 2) Isolate how THC:CBD-e-gel consumption during adolescence modifies neural activity across mesocorticolimbic structures during adult motivated behaviors; and 3) Define specific molecular and circuit changes in adult mesocorticolimbic brain regions resulting from THC:CBD-e-gel consumption during adolescence. The research utilizes an innovative mouse model of voluntary oral THC consumption to better understand the pharmacological, molecular, and cellular impacts of THC and THC/CBD use on adolescent brain development and adult behavioral outcomes. The project period runs from Jul 1, 2025 to Mar 31, 2030.

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