This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $939,459 over 5 years to the University of Maryland, Baltimore to investigate the effects of a contingency management (CM) intervention on brain structure, function, and cognitive performance among African American cocaine users living with and without HIV.
The study aims to evaluate whether reducing cocaine use through a 12-month CM...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $695,250 to Howard University to conduct research on the role of endothelial injury and myeloid cell migration in the activation of inflammasomes in HIV infection and cocaine exposure. The key objective is to characterize myeloid cell populations and evaluate the accumulation of perivascular macrophages and microglia in the brains of...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $779,613 to the San Diego Biomedical Research Institute to study the molecular effects of cannabinoids on the blood-brain barrier in the context of HIV infection. The research will model the human blood-brain barrier using in vitro cell systems and validate findings in vivo using an animal model to understand the dichotomous influence of...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $2,055,051 in funding to Case Western Reserve University to conduct ex vivo research on the impact of poly-substance use on crosstalk between microglia, astrocytes, and neurons that regulates HIV latency. The award period runs from May 15, 2024 to February 28, 2029. The research aims to investigate how exposure to combinations of methamphetamine...
This Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $454,470 to Drexel University to develop a new imaging pipeline that examines epigenetic spatial architecture in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to understand the mechanisms by which altered histone dopaminylation in astrocytes may contribute to increased sensitivity to...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) totaling $263,119 will fund research to develop novel NLRP3 inhibitor compounds for treating HIV-associated neuroinflammation and cognitive impairment in individuals with cocaine use disorder.
The primary research objectives are to: 1) computationally design and synthesize analogs of a lead NLRP3 inhibitor compound, 2) screen the new analogs in...
This federal Project Grant award from the National Institute on Drug Abuse, under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $157,568 to Drexel University to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the comorbidity of HIV and cocaine use disorders (CUDs). The research aims to use circuit-specific optogenetics and chemogenetics techniques to understand how HIV infection, particularly the EcoHIV model, dysregulates reward-seeking...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $1,410,154 in funding over the period of Sep 30, 2024 to May 31, 2029 to The Medical University of South Carolina (MUSC).
The grant supports research to investigate the mechanisms by which drug abuse, particularly cocaine and cannabis use, impact the development of pathogenic anti-CD4 autoantibodies and impair immune reconstitution in...
This federal Project Grant award for $983,672.00, provided by the National Institute on Drug Abuse under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a research project titled "In Situ Spatial Characterization of CNS HIV-Host Cellular Interactions from Victims of Sudden Death."
The key objectives of this project are to: 1) Implement innovative spatial multi-omic assays to analyze the localization, distribution, and activity of HIV-infected cells and host...
This $2,426,074 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Federal Grant Program for Drug Use and Addiction Research Programs (CFDA 93.279) aims to study the effects of different medications for opioid use disorder (MOUD) on immune activation and neurocognition in people living with HIV (PLWH).
The research will longitudinally assess cerebrospinal fluid biomarkers of neuroinflammation, neuronal injury, and myeloid cell activation in PLWH receiving either...