This Project Grant award for $1,032,192 was provided by the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279). The project aims to conduct a comprehensive, cell-type based epigenomic analysis to identify druggable genes for people living with HIV infection who also use cannabis. The research will involve profiling DNA methylation patterns across five different cell types isolated from peripheral blood mononuclear cells, alongside...
This $695,250 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the role of endothelial injury and myeloid cell migration in the activation of inflammasomes in HIV infection and cocaine exposure. The research, led by Howard University, aims to characterize myeloid cell populations in the brains of HIV-transgenic mice under chronic cocaine treatment, and evaluate the accumulation of...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) provides $441,154 to investigate the molecular mechanisms by which HIV, cocaine, and antiretroviral therapy (ART) interact to drive neuroinflammation through microglial pyroptosis. The research aims to elucidate how these factors collectively contribute to microglial activation and exacerbate neuroinflammation, a significant challenge in managing...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $454,470 to Drexel University to develop a new imaging pipeline to examine epigenetic spatial architecture in the central nervous system (CNS) of mice with HIV infection that self-administer cocaine. The goal is to understand the mechanisms by which HIV infection enhances the neurobehavioral effects of cocaine, with a focus on the role of histone...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to elucidate the corticolimbic circuit and neuroimmune mechanisms underlying the comorbidity of HIV and cocaine use disorders. The $157,568 award, effective from November 13, 2024 to June 30, 2026, will be used by Drexel University to conduct studies that utilize circuit-specific optogenetics and chemogenetics to understand how HIV infection and...
This federal Project Grant award, valued at $5,147,311 and issued by the National Institute on Drug Abuse (NIDA, CFDA 93.279 - Drug Use and Addiction Research Programs), supports research to investigate the impact of HIV infection and cocaine use on the integrity of the blood-brain barrier (BBB) in people living with HIV (PLWH). The key objectives are to: 1) Determine how immune cell phenotypes and HIV proviral DNA burden in monocytes and T cells contribute to BBB permeability in PLWH with and...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $3,717,777 in funding to the Icahn School of Medicine at Mount Sinai to investigate the impact of nicotine and HIV-1 infection on neuroinflammation and cognitive decline. The research aims to elucidate the role of the NLRP3 inflammasome in HIV-1-associated inflammation, with the goal of identifying potential therapeutic targets to address cognitive...
This $714,783 federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports a comprehensive research initiative to investigate the intersection of HIV infection and opioid use on inflammasome activation, neuroinflammation, and neurotoxicity. The project will employ neuropathology, ex vivo, and in vitro methodologies to analyze brain tissue samples from persons with and without HIV, and with varying...
This $492,000 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to elucidate the genetic and epigenetic mechanisms underlying cocaine addiction using a multidisciplinary approach. The key objectives are to: 1) conduct high-resolution epigenomic profiling to uncover cell-type and circuit-specific changes after cocaine self-administration in mice, 2) leverage the Hybrid Mouse Diversity Panel to...
This $1,790,186 Project Grant awarded by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to investigate the mechanisms governing stress-immune interactions in people living with HIV (PLWH) and their associated distress and cannabis use disorder (CUD). The research project will use a cross-diagnostic approach to: Determine the hypothalamic-pituitary-adrenal (HPA) and immune response to acute stress among healthy controls, PLWH,...