Project Grant R01CA314054
- Federal Project Grant Award Summary New York University received a $1,345,320 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded August 21, 2025, with completion expected by August 20, 2027. The project, "Fibronectin Modulation of Oral Cancer Nociception," addresses the critical clinical need for non-opioid analgesics to treat oral cancer pain, which intensifies in...
- Federal Project Grant Award Summary Funding Agency: National Cancer Institute (NCI) Program: Cancer Research Manpower (CFDA 93.398) Award Amount: $149,190 Award Date: December 1, 2025 Completion Date: May 6, 2027 Recipient: New York University School of Medicine New York University School of Medicine received $149,190 in federal project grant funding from the National Cancer Institute to support research training and workforce development in cancer biology. The award funds biomedical training...
- Federal Project Grant Award Summary The National Institute of Neurological Disorders and Stroke awarded $7.78 million to the University of Virginia under the Oral Diseases and Disorders Research program (CFDA 93.121) to develop innovative pain management strategies for oral and head and neck cancer patients. Initiated September 1, 2025, and extending through August 31, 2029, this project addresses the clinical inadequacy of high-dose opioid analgesics by investigating succinate signaling through...
- Federal Project Grant Award Summary New York University received a $427,085 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393) awarded on August 7, 2025, with completion targeted for July 31, 2027. The grant funds research investigating the relationship between social determinants of health (SDOH)—including food insecurity, dietary quality, and neighborhood-level socioeconomic factors—and cancer-related fatigue (CRF) in...
- Federal Project Grant Award Summary New York University School of Medicine received a $684,529 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective July 1, 2026 through June 30, 2031. This fundamental cancer biology research project investigates SHP2 (PTPN11) signaling mechanisms, focusing on understanding how this protein-tyrosine phosphatase functions as a positive regulator of receptor tyrosine kinase (RTK) signaling...
- Federal Project Grant Award Summary New York University received a $442,750 Project Grant award from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), with performance extending from September 23, 2025 through August 31, 2027. This research initiative delivers a systematic, theory-driven analysis of implementation strategies for cervical cancer control policies in African low- and middle-income countries (LMICs). The project employs a rigorous...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $410,545 to The Research Foundation For The State University of New York under the Cancer Treatment Research program (CFDA 93.395) for a Project Grant effective May 1, 2026 through April 30, 2028. The award supports research assessing the role of efflux transport mechanisms, pharmacokinetics, and systems pharmacology in monomethyl auristatin E (MMAE)-induced neurotoxicity associated with antibody-drug conjugate (ADC)...
- Federal Grant Award Summary New York University School of Medicine received a $585,482 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396) awarded June 1, 2026, with completion targeted for May 31, 2031. This research grant funds fundamental investigation into the molecular mechanisms of breast cancer metastasis, specifically examining the role of the translation factor DAP5 (Death-Associated Protein 5) in selective messenger ribonucleic...
- Federal Project Grant Award Summary New York University School of Medicine received a $315,246 Project Grant award from the National Cancer Institute under the Cancer Research Manpower program (CFDA 93.398), effective August 1, 2025, through July 31, 2030. This five-year research initiative, titled "Breaking Cytokine Loops in Lung Adenocarcinoma," will deliver fundamental cancer research and scientific investigation focused on understanding immune resistance mechanisms in lung cancer...
- Federal Project Grant Award Summary New York University School of Medicine received a $703,227 Project Grant awarded June 1, 2026, through the National Cancer Institute's Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop an ultra-rapid droplet digital polymerase chain reaction (ddPCR) methodology for intraoperative molecular profiling of cancer tissue samples. The project aims to translate existing genetic testing capabilities into real-time surgical applications by...
Federal Project Grant Award Summary New York University received a $667,815 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) awarded July 1, 2026, with a completion date of June 30, 2031. This five-year research initiative investigates the composition and concentration of protease-activated receptor 2 (PAR2)-activating proteases in the oral cancer tumor microenvironment and their contribution to heterogeneous pain phenotypes in oral cancer patients. The project addresses a critical gap in understanding how different combinations and potencies of proteases affect pain signaling through PAR2, with particular focus on non-canonical protease activation mechanisms that predominate in painful metastatic cancers. The research deliverables encompass three primary objectives: (1) identifying patient pain phenotypes associated with specific protease expression patterns in oral cancers using tissue microarray analysis and RNA in situ hybridization; (2) characterizing PAR2 signaling and pain phenotypes induced by various protease combinations at clinically relevant concentrations; and (3) developing mechanistic understanding of how protease-specific "biased agonism" contributes to oral cancer pain heterogeneity. These research outputs are intended to provide foundational knowledge for developing more targeted therapeutic interventions to manage pain in oral cancer patients based on individual tumor protease profiles.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $667.8k | 7/1/26 |