Project Grant R01CA313980
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $119,858 to the Regents of the University of Minnesota under the Cancer Biology Research program (CFDA 93.396) on August 7, 2025, for a project extending through July 31, 2030. This project grant supports fundamental research aimed at elucidating and overcoming T cell dysfunction in pancreatic ductal adenocarcinoma (PDA), a disease notoriously resistant to immunotherapy. The research program comprises three...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Michigan $175,448 under the Cancer Research Manpower program (CFDA 93.398) on January 16, 2026, with completion targeted for July 31, 2027. This project grant supports research training and investigator development in cancer biology, specifically focused on characterizing cancer-associated fibroblasts (CAFs) and their role in pancreatic ductal adenocarcinoma (PDAC). The research aims to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the Regents of the University of Michigan $646,949 under the Cancer Biology Research program (CFDA 93.396) on July 9, 2026, for research into ADAR1 (Adenosine Deaminase Acting on RNA 1) post-translational modifications in cancer immunity and immunotherapy. The five-year project, scheduled for completion by June 30, 2031, will investigate how ADAR1—an RNA editing enzyme that converts adenosine to inosine in...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Pittsburgh a Project Grant of $408,829 under the Cancer Treatment Research program (CFDA 93.395) on May 25, 2026, with completion targeted for April 30, 2028. This award supports research investigating lipogenesis-mediated resistance to cytotoxic therapy in pancreatic ductal adenocarcinoma (PDAC). The project will characterize how tumor cells upregulate lipid production following chemotherapy and...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $658,033 Project Grant to the University of Pennsylvania effective June 1, 2026, through May 31, 2031, under the Cancer Cause and Prevention Research program (CFDA 93.393). This project addresses pancreatic ductal adenocarcinoma (PDAC) through cancer interception strategies designed to eliminate premalignant lesions before progression to invasive cancer. The research focuses on translatable approaches to...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $123,823 to the University of Maryland, Baltimore under the Cancer Research Manpower program (CFDA 93.398) effective June 1, 2026, through May 31, 2028. The project, titled "Transcriptomic, Genomic, and Microenvironmental Heterogeneity in Pancreatic Precancer: Subtyping, Classification, and Cross-Comparison," supports research and training initiatives focused on characterizing the molecular mechanisms...
- Grant Award Summary The National Cancer Institute (NCI) awarded $214,993 to the Regents of the University of Michigan through the Cancer Research Manpower program (CFDA 93.398) on August 14, 2025, with a completion date of February 29, 2028. This Project Grant supports biomedical research training and workforce development focused on investigating the lipid kinase PIKFYVE as a therapeutic target in pancreatic ductal adenocarcinoma (PDAC). The research aims to establish PIKFYVE inhibition as a...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $136,412 to the Regents of the University of Michigan, effective August 1, 2025 through July 31, 2027, under the Cancer Research Manpower program (CFDA 93.398). This award funds research aimed at defining and interrupting metabolic crosstalk in the glioblastoma microenvironment. The research builds upon preliminary findings demonstrating that glioblastoma (GBM) tumors acquire nutrients through...
- Federal Grant Award Summary The University of Miami's Office of Research Administration - School of Medicine Division received a $110,228 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398) awarded December 1, 2026, with completion scheduled for May 31, 2029. This award funds biomedical research training and workforce development focused on pancreatic ductal adenocarcinoma (PDAC) microenvironment remodeling. The project investigates how...
- Federal Grant Award Summary Purdue University received a $915,006 Project Grant award from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective August 28, 2025, through July 31, 2030. The grant funds fundamental research on posttranslational regulation of macropinocytosis in pancreatic ductal adenocarcinoma (PDAC), a highly aggressive cancer with poor patient survival rates. The research investigates how protein phosphatase 2A (PP2A),...
The National Cancer Institute (NCI) awarded $400,614 through its Cancer Biology Research program (CFDA 93.396) to the University of Michigan, effective July 6, 2026, with a completion date of June 30, 2031. This Project Grant supports fundamental research investigating uridine metabolism as a therapeutic target in pancreatic ductal adenocarcinoma (PDA). The research addresses a critical gap in cancer treatment, as PDA is projected to become the second leading cause of cancer death in the United States by 2030. The project will deliver scientific discoveries regarding how pancreatic cancer cells utilize uridine as an alternative fuel source under nutrient-restricted conditions and will characterize the role of uridine phosphorylase 1 (UPP1) in supporting tumor growth and immune suppression. The research deliverables will include molecular and biochemical analyses using mass spectrometry to identify uridine sources available to pancreatic cancer cells, mechanistic studies defining pathways that regulate UPP1 expression, and preclinical tumor models to evaluate whether disrupting uridine metabolism can facilitate immune cell infiltration and tumor control. Results from this five-year investigation are expected to establish foundational knowledge supporting the development of novel therapeutic strategies targeting uridine metabolism in pancreatic cancer and potentially inform treatment approaches for other nutrient-scavenging cancers.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $400.6k | 7/7/26 |