Project Grant R01CA311218
- This Cooperative Agreement awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) provides $1,281,520.00 in funding to The Leland Stanford Junior University to conduct research on the fundamental biological mechanisms of cancer metastasis, organ tropism, and immune evasion. The project aims to integrate genetic barcoding with single-cell profiling to uncover the key molecular drivers underlying metastatic fitness and diverse cancer cell states in pancreatic ductal...
- This federal Project Grant award of $640,522 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) to The Leland Stanford Junior University supports research to elucidate how microbial microproteins modulate macrophage function, a critical coordinator of tumor immune response. The project aims to carry out high-throughput screens of thousands of microbial macromolecules to identify those that directly modulate macrophages, with the goal of enhancing cancer immunotherapy...
- This federal Project Grant award, valued at $469,381.00, was provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) to The Leland Stanford Junior University. The award period runs from April 15, 2025 to April 14, 2027. The purpose of this grant is to fund research focused on "ENGINEERING CYTOTOXIC LYMPHOCYTES TO INFILTRATE OVARIAN CANCER TUMORS VIA METABOLITE-SENSING RECEPTORS". This advanced biomedical research aims to transform...
- This federal Project Grant award, funded by the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), supports research focused on understanding the relationship between inflammatory signaling in the leptomeninges and the growth of leptomeningeal metastatic tumors. The $730,398 award to the Sloan-Kettering Institute for Cancer Research, located in New York, will leverage mouse models and single-cell RNA sequencing to investigate how cancer cell signals induce...
- This federal Project Grant award, funded by the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program), provides $170,655.00 to The Leland Stanford Junior University to develop a new molecular method for mapping protein trafficking between glioblastoma (GBM) cells and other brain cell populations in an in vivo setting. The goal is to gain a detailed understanding of the intercellular crosstalk, including protein translocation, that occurs within the GBM tumor...
- This $113,147 Project Grant award was provided by the National Cancer Institute under the Cancer Research Manpower (CFDA 93.398) federal grant program. The grant supports a 5-year career development program for Dr. Chris McGinnis at Stanford University to conduct research on tumor-immune interactions during metastasis. The goal is to leverage longitudinal single-cell RNA sequencing and high-throughput chemical compound screening to improve the understanding of pro-metastatic immune remodeling...
- This federal Project Grant award of $584,521 was provided by the National Cancer Institute (CFDA 93.395 - Cancer Treatment Research) to The Leland Stanford Junior University (Stanford University) on August 8, 2025. The grant supports a research study to understand the non-genetic mechanisms that enable subclonal tumor populations to survive radiotherapy for soft tissue sarcomas. The key objectives are to: 1) identify and validate epigenetic changes that cause subclonal radioresistance, 2) define...
- This federal Project Grant award of $187,887 from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program) is supporting research at The Leland Stanford Junior University (Stanford University) to explore the role of extrachromosomal DNA (ecDNA) in HER2-amplified breast cancer. The key objectives are to investigate how HER2 ecDNA drives genome instability and treatment resistance in HER2-positive breast cancer, and to evaluate if combined targeting of HER2 and the S phase...
- This federal Project Grant award of $2,808,108.00, provided by the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420), supports research conducted by the Sloan-Kettering Institute for Cancer Research to investigate the role of clonal hematopoiesis in therapeutic resistance and metastatic relapse in breast cancer. The award period extends from March 1, 2024 to February 29, 2028. Through this funding, the Sloan-Kettering Institute will explore the...
- The federal Project Grant award of $924,001.00 was provided by the Defense Health Agency under the Military Medical Research and Development (CFDA 12.420) program. The grant supports research by the Sloan-Kettering Institute for Cancer Research to investigate the cellular and molecular origins of non-small cell lung cancer (NSCLC) brain metastasis. The research aims to enhance understanding of the mechanisms driving NSCLC brain metastasis, with the goal of developing innovative therapeutic...
This federal Project Grant award of $1,033,055.00 was provided by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The funding supports research aimed at understanding and targeting the mechanisms of cancer metastasis. The project, titled "Targeting Cancer Metastasis by Inhibiting Curvature-Induced Kinase Activation," seeks to unravel the molecular pathways underlying how cancer cells acquire the ability to survive while detached from the primary tumor and migrate to new locations. The research is being conducted by The Leland Stanford Junior University, a leading academic research institution, with an award period from September 8, 2025 to August 31, 2030. The findings from this project have the potential to inform the development of new therapies that disrupt the metastatic process and reduce cancer-associated deaths.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/17/25 | ||
| Not listed | $1.0m | 9/5/25 |