Project Grant R01CA310971
- Federal Project Grant Award Summary The University of Wisconsin–Madison received a $508,651 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded June 2, 2026, with a completion date of May 31, 2031. This research initiative will deliver fundamental cancer biology research focused on understanding and therapeutically exploiting the role of the neuropeptide receptor PAC1 (pituitary adenylate cyclase-activating polypeptide...
- Federal Project Grant Summary The National Cancer Institute (NCI) awarded a $694,133 Project Grant to Weill Medical College of Cornell University on May 14, 2026, under the Cancer Biology Research program (CFDA 93.396). This five-year award, with an ultimate completion date of April 30, 2031, funds fundamental research investigating how axonal signaling from the sympathetic nervous system controls melanoma tumor progression and resistance to therapy. The project focuses on defining cell types...
- Federal Grant Award Summary The National Cancer Institute awarded The University of Texas MD Anderson Cancer Center a $645,865 Project Grant under the Cancer Biology Research program (CFDA 93.396) beginning July 1, 2026, and concluding June 30, 2031. This five-year research initiative focuses on understanding and disrupting the neuroimmune feedback mechanisms that drive immunotherapy resistance in cutaneous squamous cell carcinoma (CSCC) with perineural invasion (PNI). The research will...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $410,545 to The Research Foundation For The State University of New York under the Cancer Treatment Research program (CFDA 93.395) for a Project Grant effective May 1, 2026 through April 30, 2028. The award supports research assessing the role of efflux transport mechanisms, pharmacokinetics, and systems pharmacology in monomethyl auristatin E (MMAE)-induced neurotoxicity associated with antibody-drug conjugate (ADC)...
- Federal Grant Award Summary The National Cancer Institute's Cancer Biology Research program (CFDA 93.396) awarded a $661,721 Project Grant to the University of California, San Diego, effective April 1, 2026, through March 31, 2031. This award supports systematic functional mapping and interrogation of oncogenic intrinsically disordered regions (IDRs) in cancer driver proteins. The research will utilize high-throughput functional screening technologies to perform domain and residue-level...
- Federal Grant Award Summary The University of Wisconsin-Madison received a $2.58 million Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), awarded August 11, 2025, and extending through July 31, 2030. This multi-institutional research program investigates the molecular drivers and therapeutic susceptibilities in lineage state transitions of metastatic castrate-resistant prostate cancer (MCRPC). The project addresses critical...
- Federal Project Grant Award Summary The University of Wisconsin-Madison received a $630,171 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), effective August 12, 2025, with a completion date of July 31, 2030. The award supports the development of targeted radiopharmaceutical therapies (RPTs) for triple-negative breast cancer (TNBC), an aggressive breast cancer subtype that lacks expression of estrogen receptor, progesterone...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. a Project Grant of $433,256 under the Cancer Treatment Research program (CFDA 93.395) for the period of September 1, 2025 through August 31, 2027. This award supports exploratory research into the role of antisense ribonucleic acids (asRNAs) in melanoma development and transformation. The project will deliver scientific research and analysis focused on...
- Federal Grant Award Summary New York University School of Medicine received a $695,852 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) awarded May 1, 2026, with completion scheduled for April 30, 2031. The research investigates T cell circuits within the lymphatic system during melanoma progression, specifically examining tumor-draining lymph nodes (TDLNs) as critical hubs for anti-tumor immune surveillance. The project focuses on...
- Federal Project Grant Award Summary The University of Wisconsin–Madison received a $216,013 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research project investigates the mechanisms by which Kaposi's sarcoma-associated herpesvirus (KSHV) hijacks cellular caspase enzymes to suppress interferon responses and develop targeted therapeutic strategies to block viral...
The National Cancer Institute (NCI) awarded a $585,625 Project Grant to the University of Wisconsin–Madison under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2026, through June 30, 2031. This five-year research initiative focuses on defining and exploiting the role of the nociceptor neuron-tumor-pericyte axis that drives melanoma progression via Calcitonin Gene-Related Peptide (CGRP)–Receptor Activity-Modifying Protein 1 (RAMP1) signaling. The research seeks to characterize how nervous system-tumor microenvironment interactions regulate metastatic melanoma disease progression and to identify novel therapeutic targets for overcoming treatment resistance. The project delivers fundamental cancer biology research through experimental investigation of nociceptor neuron involvement in melanoma metastasis. Deliverables include scientific validation of the CGRP-RAMP1 signaling pathway as a therapeutic target through in vitro studies, single-cell RNA-sequencing analysis of human melanoma specimens, and preclinical evaluation of pharmacologic RAMP1 blockade on melanoma cell migration, growth, and tumor-associated angiogenesis. The research addresses a critical gap in understanding peripheral nerve system contributions to cancer progression and is expected to generate findings supporting the development of novel immunotherapeutic and targeted approaches to metastatic melanoma, a disease representing the most lethal form of skin cancer.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $585.6k | 6/29/26 |