Project Grant R37CA300434
- Federal Grant Award Summary The University of Wisconsin-Madison received a $2.58 million Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394), awarded August 11, 2025, and extending through July 31, 2030. This multi-institutional research program investigates the molecular drivers and therapeutic susceptibilities in lineage state transitions of metastatic castrate-resistant prostate cancer (MCRPC). The project addresses critical...
- Federal Project Grant Award Summary The University of Wisconsin–Madison received a $216,013 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396) effective September 1, 2025, through August 31, 2027. This research project investigates the mechanisms by which Kaposi's sarcoma-associated herpesvirus (KSHV) hijacks cellular caspase enzymes to suppress interferon responses and develop targeted therapeutic strategies to block viral...
- Federal Project Grant Award Summary The University of Wisconsin-Madison received a $630,171 Project Grant award from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), effective August 12, 2025, with a completion date of July 31, 2030. The award supports the development of targeted radiopharmaceutical therapies (RPTs) for triple-negative breast cancer (TNBC), an aggressive breast cancer subtype that lacks expression of estrogen receptor, progesterone...
- Federal Grant Award Summary The National Cancer Institute awarded The Johns Hopkins University a $510,431 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective July 1, 2025 through June 30, 2030. This award supports fundamental research investigating the mechanisms of metastatic recurrence and therapeutic resistance in melanoma, with particular emphasis on understanding how aging influences tumor dormancy and the microenvironment. The research examines Wnt signaling...
- Federal Grant Award Summary The National Cancer Institute awarded a $689,340 Project Grant to the University of Wisconsin-Madison on June 1, 2026, under the Cancer Cause and Prevention Research program (CFDA 93.393) to conduct a five-year research initiative examining symptom trajectories in children with advanced cancer. The project will define symptom patterns over time among pediatric patients aged 8-18 with metastatic, relapsed, or refractory cancer; identify biopsychosocial...
- Federal Project Grant Award Summary New York University School of Medicine received a $695,852 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), awarded on May 1, 2026, with a completion date of April 30, 2031. The award funds fundamental research investigating T cell circuits in the lymphatic system during melanoma progression, specifically examining tumor-draining lymph nodes (TDLNs) as key immune surveillance hubs. The research...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Weill Medical College of Cornell University a $694,133 project grant on May 14, 2026, under the Cancer Biology Research program (CFDA 93.396) to conduct fundamental research on axonal control of tumor progression in melanoma. The research project, which extends through April 30, 2031, focuses on defining how sympathetic nervous system axons inhibit melanoma growth through interactions with immune effectors in the...
- Federal Project Grant Award Summary The University of Wisconsin-Madison received a $603,981 Project Grant from the National Cancer Institute under the Cancer Detection and Diagnosis Research Program (CFDA 93.394) awarded August 18, 2025, with completion targeted for July 31, 2030. This research initiative develops and validates integrated clinical-grade artificial intelligence (AI) biomarkers combining genomic and digital pathology analysis to improve risk stratification and treatment...
- Federal Grant Award Summary The National Cancer Institute awarded the University of Wisconsin–Madison a $634,644 Project Grant on March 12, 2026, under the Cancer Treatment Research program (CFDA 93.395) to support research into treatment of neuroinflammation associated with chemoradiation-induced dysphagia. The research extends through February 28, 2031, and involves preclinical investigation using a rat animal model to evaluate the efficacy of glibenclamide (GLC) pharmaceutical intervention...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded Boston University Medical Campus a five-year Project Grant totaling $534,325 under the Cancer Cause and Prevention Research program (CFDA 93.393), effective June 1, 2026 through May 31, 2031. The grant funds basic biomedical research investigating the transcriptional and post-transcriptional regulatory mechanisms of PAX3 (Paired Box 3) protein in melanoma progression. The research will characterize PAX3's role as...
The University of Wisconsin–Madison received a $508,651 Project Grant award from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), effective June 2, 2026 through May 31, 2031. The research project focuses on defining and therapeutically exploiting the role of the neuropeptide receptor PAC1 (pituitary adenylate cyclase-activating polypeptide receptor 1) in tumor-infiltrating pericytes that drive melanoma progression. The research will advance fundamental understanding of cancer biology mechanisms by investigating the interplay between melanoma-infiltrating neurons and pericytes in the tumor microenvironment, with the goal of identifying novel therapeutic targets to improve treatment outcomes for melanoma, the most lethal form of skin cancer. The funded research will employ multiple investigative approaches including chemogenetic silencing of PACAP+ (pituitary adenylate cyclase-activating peptide-positive) neurons, single-cell RNA sequencing, immunohistochemistry, and flow cytometry to elucidate the mechanisms by which PAC1 expression in pericytes influences melanoma advancement and metastasis. This fundamental cancer biology research aligns with the Cancer Biology Research program's objectives to provide essential information on cancer cause and nature that will ultimately support development of improved prevention, detection, diagnosis, and treatment methods for neoplastic diseases.Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $508.7k | 6/1/26 |