Project Grant R01CA309136
- Federal Grant Award Summary The National Cancer Institute (NCI), under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded $641,419 to Washington University's Office of Sponsored Research Services on May 7, 2026, for clinical translation research of a novel Meitner-Auger electron (MAE) positron emission tomography (PET) theranostic agent. The project, extending through April 30, 2031, focuses on developing and evaluating [77Br]Br-WC-DZ, a stable bromine-77 ligand targeting...
- Federal Grant Award Summary Wayne State University's Sponsored Project Administration Division received a $155,000 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded May 1, 2026, with completion by April 30, 2028. The grant funds research to identify multi-level predictors of diagnostic follow-up (DFU) completion after abnormal cervical cancer screening results. The project addresses a critical gap in cervical cancer...
- Federal Project Grant Summary Emory University received a $402,401 Project Grant award on May 6, 2026, from the National Cancer Institute under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop an 18F-labeled positron emission tomography (PET) imaging agent for detecting mutated isocitrate dehydrogenase 1 (IDH1-R132H) expression in gliomas. The grant supports synthesis and evaluation of six rationally designed 19F-heteroaromatic derivatives based on AG-881 and...
- Federal Grant Award Summary The National Cancer Institute awarded $2.82 million to the Regents of the University of Michigan under the Cancer Treatment Research program (CFDA 93.395) on August 6, 2025, with completion targeted for July 31, 2029. This Project Grant supports the development of new methods to measure metabolic pathway activity in glioblastomas (GBMs), deadly brain cancers that rewire their metabolism to enable growth, invasion, and treatment resistance. The research deliverables...
- Federal Grant Award Summary Wayne State University received a $371,024 Project Grant from the National Cancer Institute (NCI) under the Cancer Biology Research program (CFDA 93.396), effective April 1, 2026 through March 31, 2031. The award supports fundamental research investigating the noncanonical signaling mechanisms of Janus Kinase 1 (JAK1) and Janus Kinase 2 (JAK2) in mammary gland development and breast cancer. The research project deliverables include scientific findings on how JAK1...
- Federal Grant Award Summary Wayne State University received a $366,618 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective August 1, 2025 through July 31, 2030. The grant funds a research investigation examining socio-genomic associations related to survival outcomes among women diagnosed with endometrial cancer in the Detroit metropolitan area. The research team, composed of population scientists, bioinformatics researchers,...
- Federal Grant Award Summary The Medical College of Wisconsin, Inc. received a $602,121 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), effective June 1, 2026 through May 31, 2031. The grant funds research to develop and validate advanced radio-pathomic mapping techniques that predict pathological tumor characteristics in glioblastoma (GBM) using standard clinical MRI imaging. The project leverages the world's largest...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under its Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded $674,339 to the University of Pennsylvania on June 1, 2026, for a five-year project extending through May 31, 2031. The research focuses on developing translational imaging markers to enhance immunotherapy efficacy in triple-negative breast cancer (TNBC) by targeting glutamine metabolism. The project will validate the use of...
- Federal Project Grant Award Summary Award Details: Case Western Reserve University received a $630,108 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), awarded March 13, 2026, with completion targeted for February 28, 2030. The research will be conducted in Cleveland, Ohio in affiliation with University Hospitals of Cleveland. Research Scope and Deliverables: This project develops and validates theranostic...
- Federal Project Grant Summary Zeest Bio Inc. received a $400,000 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop a novel liver-specific Positron Emission Tomography (PET) tracer. The award, effective September 15, 2025, with completion targeted for August 31, 2026, supports preclinical testing and Investigational New Drug (IND)-enabling studies in preparation for first-in-human clinical trials. The tracer...
Wayne State University received a $513,901 Project Grant from the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), effective July 1, 2026 through June 30, 2031. The grant supports translational research to develop and validate a novel fluorine-18-labeled positron emission tomography (PET) radiotracer, [18F]fluoroethyl-L-tryptophan ([18F]FETRP), for improved detection and characterization of human glioblastoma tumors. The project addresses the clinical need for more accurate pre- and post-treatment glioma evaluation by targeting tryptophan metabolism via the kynurenine pathway, an immunosuppressive mechanism that contributes to glioma immune tolerance. The research deliverables include development of PET-derived tryptophan kinetic parametric mapping techniques to detect glioblastoma extent in pre-radiotherapy patients, including non-enhancing brain regions, and validation of [18F]FETRP parametric maps to differentiate post-treatment tumor progression from radiation injury. Building upon prior proof-of-concept studies with a shorter-lived carbon-11 variant, this project translates the technology toward clinical feasibility through multi-modal imaging integration and advanced analytical approaches with the ultimate objective of improving patient survival outcomes through enhanced targeted glioma treatment planning and monitoring.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $513.9k | 6/25/26 |