Project Grant R01CA308828
- Federal Project Grant Award Summary Virginia Commonwealth University received a $634,062 Project Grant from the National Cancer Institute under the Cancer Biology Research program (CFDA 93.396), awarded June 5, 2026, with completion targeted for May 31, 2031. The award funds research on atypical sphingolipids in hepatocellular carcinoma (HCC), a leading cause of cancer-related death. The research will investigate the role of serine palmitoyltransferase long-chain base subunit 3 (SPTLC3), a novel...
- Federal Project Grant Summary Virginia Commonwealth University received a $399,187 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on May 7, 2026, with completion scheduled for April 30, 2028. This translational exploratory/developmental research project focuses on developing a theragnostic approach utilizing glycosaminoglycans (GAGs)—specifically heparan sulfate and chondroitin sulfate—to overcome platinum resistance in...
- Federal Project Grant Award Summary Virginia Commonwealth University received a $403,586 Project Grant from the National Cancer Institute (Cancer Biology Research program, CFDA 93.396) beginning August 1, 2025, and concluding July 31, 2027. The award supports research to develop codon-specific isotope labeling technology for nuclear magnetic resonance (NMR) resonance assignment. This novel methodology addresses critical obstacles in characterizing intrinsically disordered proteins (IDPs),...
- Federal Project Grant Award Summary Virginia Commonwealth University received a $399,187 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective July 1, 2026 through June 30, 2028. The award supports research to explore a novel therapeutic approach targeting advanced prostate cancer, specifically castration-resistant prostate cancer (CRPC) that has developed resistance to enzalutamide (ENZ), a frontline treatment agent. The...
- Federal Grant Award Summary Virginia Commonwealth University received a $1.79M Project Grant from the Defense Health Agency under the Military Medical Research and Development program (CFDA 12.420) awarded September 1, 2025, with completion targeted for August 31, 2029. The research project, "Targeting Ganglioside GD2 to Overcome Chemotherapy Resistance in Triple-Negative Breast Cancer," focuses on developing innovative therapeutic approaches to address chemotherapy resistance in...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $431,970 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) to investigate mechanisms of resistance to anti-TROP2 (tumor-associated glycoprotein 2) antibody-drug conjugates, specifically sacituzumab govitecan (SG). The award, effective April 1, 2026 through March 31, 2028, supports the development and characterization of novel humanized TROP2 mouse...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant totaling $482,236 to Sloan-Kettering Institute for Cancer Research under the Cancer Treatment Research program (CFDA 93.395) on August 1, 2025, with a project completion date of July 31, 2030. This investigator-initiated Phase 2 clinical trial will evaluate the safety and efficacy of combining trastuzumab deruxtecan (T-DXD), an antibody-drug conjugate, with the anti-EGFR (epidermal growth factor receptor)...
- Federal Grant Award Summary The National Cancer Institute awarded a $736,168 Project Grant to Sloan-Kettering Institute for Cancer Research (award date: August 1, 2025; completion date: July 31, 2030) under the Cancer Treatment Research program (CFDA 93.395) to develop novel antibody-drug conjugates (ADCs) and antibody-oligonucleotide conjugates (AOCs) designed to enhance radiotherapy efficacy through antigen-specific radiosensitization. The research focuses on delivering potent DNA damage...
- Federal Grant Award Summary The National Cancer Institute awards $161,500 to the University of Virginia under the Cancer Biology Research program (CFDA 93.396) for a two-year project (June 1, 2026–May 31, 2028) focused on advancing detection and classification of circulating tumor cells (CTCs) from pancreatic ductal adenocarcinoma (PDAC) patients. The project develops complementary biophysical metrics to immunofluorescence imaging by leveraging single-cell deformability analysis to identify...
- Federal Grant Award Summary The University of Virginia received a $415,257 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), effective July 1, 2026 through June 30, 2028. The grant funds development of a comprehensive intervention to address financial toxicity (FT)—a multidimensional construct encompassing material burden, psychosocial distress, and coping behaviors driven by financial strain—among cancer survivors and...
Federal Grant Award Summary Virginia Commonwealth University received a $511,930 Project Grant award from the National Cancer Institute (CFDA 93.395: Cancer Treatment Research) effective August 1, 2026 through July 31, 2031. The research project, "Potentiating Efficacy of TROP2-Targeted Antibody-Drug Conjugates," focuses on enhancing the therapeutic effectiveness of sacituzumab govitecan (SG), an FDA-approved antibody-drug conjugate targeting the TROP2 glycoprotein for triple-negative breast cancer and pancreatic adenocarcinoma treatment. The project will deliver three primary research products: (1) proteogenomic biomarkers and a machine-learning predictive tool (SG-Predictor) to identify patient sensitivity and resistance to ADC therapy; (2) mechanistic characterization of acquired resistance pathways involving TROP2 expression, drug internalization, efflux mechanisms, and DNA repair alterations using patient-derived xenografts and organoids; and (3) validated therapeutic strategies combining rational drug combinations and next-generation ADC payloads to enhance and prolong SG efficacy. These research outputs are intended to inform precision oncology approaches, improve patient selection criteria, and guide rational clinical trial design to extend survival outcomes in solid tumor populations. The research leverages multi-omic analyses integrating genomic, transcriptomic, and proteomic profiling with high-throughput drug response data to identify predictive biomarkers and elucidate resistance mechanisms, with validation conducted through in vivo animal models to assess biodistribution and systemic toxicity profiles.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $511.9k | 6/30/26 |