The National Cancer Institute (NCI) awarded a $646,739 Project Grant under the Cancer Biology Research program (CFDA 93.396) to Cedars-Sinai Medical Center in Los Angeles, California. The grant, titled "Steatotic Liver Promotes Metastatic Niche: Role of Hepatic Stellate Cells," will fund a 5-year research project to investigate the molecular mechanisms by which obesity and metabolic dysfunction-associated steatotic liver disease (MASLD) promote liver metastasis in gastrointestinal cancers. The research will focus on understanding the differential roles of intra-tumoral and extra-tumoral hepatic stellate cells, as well as the impact of extracellular matrix modification on metastatic progression in MASLD. The findings could provide new insights to improve outcomes for cancer patients with liver metastases, especially those with underlying MASLD.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $646.7k | 3/28/25 |