This Project Grant award from the National Cancer Institute (CFDA Program 93.396 - Cancer Biology Research) totaling $2,397,277 will support research at the Sanford Burnham Prebys Medical Discovery Institute to investigate the role of metabolic stress and hypernutrition in the progression from non-alcoholic steatohepatitis (NASH) to hepatocellular carcinoma (HCC). The research will focus on understanding how interactions between cellular signaling pathways (NRF2, ATF6) and mitochondrial dysfunction (STARD1, SAB) contribute to NASH-driven HCC development. This multi-project program will utilize advanced techniques like gene editing, metabolic profiling, and single-cell genomics to elucidate the underlying mechanisms and identify potential therapeutic targets. Collaborative sub-awards with the University of California, San Diego, University of Southern California, and Fundacio De Recerca Clinic Barcelona-Institut D'investigaciones Biomediques August Pi I Sunyer will support various aspects of the research, including studying NRF2-FBP1 regulation, ATF6-driven mechanisms, and the role of mitochondrial proteins in NASH-HCC progression.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $2.4m | 9/9/24 |
Grant Number | Description | Subgrantee | Prime Award | Dollars Obligated (Click to sort descending) | Updated At (Click to sort ascending) |
|---|---|---|---|---|---|
7130713873UCSDS | University Of California, San Diego | Project Grant P01CA281819 | $457.0k | 12/10/24 | |
7130713875USCS | University Of Southern California | Project Grant P01CA281819 | $328.3k | 12/3/24 | |
7130714002IDIBAPSS | Fundacio De Recerca Clinic Barcelona-Institut D’investigacions Biomediques August Pi I Sunyer | Project Grant P01CA281819 | $161.1k | 11/20/24 | |
7130713878UCSDS | University Of California, San Diego | Project Grant P01CA281819 | $285.9k | 10/31/24 |