Project Grant R01CA300960
- Federal Project Grant Award Summary The National Cancer Institute awarded $544,250 to the University of Nebraska Medical Center (UNMC) under the Cancer Treatment Research program (CFDA 93.395) for a five-year project running from August 4, 2025 through July 31, 2030. The award supports research investigating the immune drivers of persistent oncogenic human papillomavirus (HPV) infections in people living with HIV (PLWH), with an initial focus on oral HPV persistence as a precursor to...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the Board of Regents of the University of Nebraska Medical Center a $651,038 Project Grant under the Cancer Treatment Research program (CFDA 93.395) for the period May 1, 2026 through April 30, 2031. The award supports research to understand the tumor-suppressive functions of Protein Phosphatase 2A (PP2A) in colorectal cancer (CRC) treatment. The research focuses on developing and evaluating small molecule activators of PP2A...
- Federal Grant Award Summary The National Cancer Institute awarded $125,619 to the Stowers Institute for Medical Research under the Cancer Cause and Prevention Research program (CFDA 93.393) effective August 1, 2025, through July 31, 2030. This Project Grant supports research into centromere biology and chromosome segregation mechanisms that contribute to genomic instability—a hallmark of cancer development. The primary deliverables include experimental research characterizing how natural...
- Federal Project Grant Award Summary The National Cancer Institute (NCI), under the Cancer Biology Research program (CFDA 93.396), awarded Columbia University's Health Sciences Division a $501,422 Project Grant effective May 1, 2026, through April 30, 2031, to advance research on synthetic lethal (SL) targeting in cancer. This research builds upon the institution's established expertise in identifying and characterizing SL drug targets and seeks to validate and mechanistically characterize the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $323,860 Project Grant to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) on August 18, 2025, with completion targeted for April 30, 2028. This award supports research investigating the role of mutagenic DNA repair pathways in cancer cell persistence and acquired drug resistance. The project focuses on understanding how cancer cells under stress from anti-cancer...
- Federal Grant Award Summary The National Cancer Institute awarded $584,510 under the Cancer Biology Research program (CFDA 93.396) to the University of Colorado-Denver on September 12, 2025, for development of high parameter spatial transcriptomics and proteomics technologies to study tumor microenvironments. The award, which extends through August 31, 2029, supports continued operations and advancement of the Human Immune Monitoring Shared Resource (HIMSR), a specialized service unit within the...
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $495,715 to the Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) on August 5, 2025, with a completion date of July 31, 2030. This award funds fundamental research to decipher the pathogenesis and therapeutic vulnerabilities in germline RUNX1-mutated acute myeloid leukemia (AML). The research focuses on understanding how germline RUNX1 mutations...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded the University of Alabama a $631,621 Project Grant under the Cancer Detection and Diagnosis Research program (CFDA 93.394) to develop an integrated top-down proteomics and phosphoproteomics platform for analyzing patient-derived ovarian cancer spheroids. The award, effective August 13, 2025, through July 31, 2028, supports the creation of personalized intact proteome maps that characterize disease states and identify markers...
- Federal Grant Award Summary New York University School of Medicine received a $149,190 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective December 1, 2025, with completion by May 6, 2027. This award supports biomedical research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The funded research project focuses on elucidating the mechanisms of DNA...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded the University of Nebraska Medical Center (UNMC) a Project Grant of $391,186 under the Cancer Treatment Research program (CFDA 93.395) effective September 1, 2025, with a completion date of August 31, 2027. This research project focuses on co-targeting insulin-like growth factor 1 receptor (IGF-1R) and glutaminase in Ewing sarcoma, a pediatric and young adult bone malignancy with poor survival outcomes once...
The National Cancer Institute awarded a $584,852 Project Grant to the University of Nebraska Medical Center (UNMC) under the Cancer Cause and Prevention Research program (CFDA 93.393) effective May 1, 2026 through April 30, 2031. This research initiative focuses on elucidating the mechanisms of genomic instability in DNA polymerase epsilon (POLE)-mutant tumors and identifying novel driver alleles that contribute to ultramutation phenotypes. The project will deliver comprehensive research outputs through multiple experimental approaches, including development of improved clinical diagnostic methodologies to identify POLE-mutant tumors and disambiguate variants of unknown significance, characterization of novel POLE driver mutations across both the exonuclease and polymerase domains, and mechanistic studies employing humanized yeast models, POLE-mutant human cell lines, knock-in mouse models, and analysis of clinical samples. The research will advance personalized cancer treatment strategies by enhancing the detection of functionally significant variants in patients with high mutation burden cancers and improved prognosis. Deliverables will include novel genetic, biochemical, and computational tools and methodologies to assess variant consequences within human cellular and protein contexts, supporting both basic science understanding of ultramutation mechanisms and practical clinical application for more accurate POLE tumor identification and variant interpretation.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $584.9k | 4/29/26 |