Project Grant R01CA300313
- Federal Project Grant Award Summary The National Cancer Institute awarded a Project Grant of $495,715 to the Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) on August 5, 2025, with a completion date of July 31, 2030. This award funds fundamental research to decipher the pathogenesis and therapeutic vulnerabilities in germline RUNX1-mutated acute myeloid leukemia (AML). The research focuses on understanding how germline RUNX1 mutations...
- Federal Project Grant Award Summary The National Cancer Institute awarded $1,034,176 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) on August 18, 2025, for a project extending through July 31, 2032. The research focuses on understanding and targeting aberrant RNA splicing in leukemia, building on the principal investigator's 13-year track record of discovering genetic alterations in hematopoietic malignancies. The project aims to...
- Federal Grant Award Summary The National Cancer Institute awarded a $2.49M Project Grant under the Cancer Biology Research program (CFDA 93.396) to the Sloan-Kettering Institute for Cancer Research, effective August 1, 2025, through July 31, 2030. This research initiative comprises three integrated projects investigating lipid metabolism as a determinant of ferroptosis sensitivity in cancer cells. Project 1, led by Dr. Xuejun Jiang at Memorial Sloan Kettering Cancer Institute, examines how...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $418,176 to Sloan-Kettering Institute for Cancer Research under the Cancer Biology Research program (CFDA 93.396) to advance programmable nucleic acid cytometry technology for isolating and analyzing rare cell populations from tumors and tissues. The three-year project, initiated September 1, 2025 and concluding August 31, 2028, focuses on continued development and validation of Programmable Enrichment via RNA...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $237,023 Project Grant under the Cancer Biology Research program (CFDA 93.396) to Harvard Medical School, effective March 13, 2026 through February 28, 2029. This award supports the development of high-throughput technological tools designed to track the fate of prematurely terminated transcripts in cancer cells. Specifically, the research focuses on alternative polyadenylation (APA) events—post-transcriptional gene...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $205,404 Project Grant to The Trustees of Columbia University in the City of New York, Health Sciences Division, under the Cancer Research Manpower program (CFDA 93.398). The award, obligated on September 6, 2025, with completion targeted for March 6, 2029, supports research aimed at dissecting the impact of genomic variants on T cell anti-tumor activity. The research focuses on identifying and mechanistically...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded $727,732 to Sloan-Kettering Institute for Cancer Research on June 3, 2025, under the Cancer Treatment Research program (CFDA 93.395) to conduct clinical and translational research aimed at improving CDK4/6 inhibitor (CDK4/6I) therapy for patients with dedifferentiated liposarcoma (DDLS). The primary deliverable is a Phase IB/II clinical trial rich in correlative science to evaluate the efficacy of palbociclib in...
- Federal Project Grant Award Summary The National Cancer Institute awarded $292,028 to Sloan-Kettering Institute for Cancer Research under the Cancer Research Manpower program (CFDA 93.398) beginning August 1, 2025, and concluding July 31, 2030. This five-year Project Grant supports research investigating genome instability associated with focal oncogene amplification (OA) and the development of therapeutic strategies to address treatment-resistant cancers. The research deliverables include...
- Federal Project Grant Award Summary The National Cancer Institute awarded Columbia University's Health Sciences Division a Project Grant of $151,263 under the Cancer Research Manpower program (CFDA 93.398) effective September 1, 2025, with completion targeted for August 31, 2027. This award supports research training and investigator development in cancer research aligned with the National Cancer Program's strategic priorities. The institutional award provides funding to develop research...
- Federal Grant Award Summary The National Cancer Institute awarded Sloan-Kettering Institute for Cancer Research a Project Grant totaling $323,860 under the Cancer Research Manpower program (CFDA 93.398), effective August 18, 2025, with completion by April 30, 2028. This award supports investigative research to elucidate the role of mutagenic DNA repair mechanisms, specifically microhomology-mediated end joining (MMEJ), during cancer cell persistence and the development of acquired drug...
The National Cancer Institute's Cancer Biology Research program (CFDA 93.396) awarded Columbia University's Health Sciences Division a $501,422 Project Grant effective May 1, 2026, through April 30, 2031, to advance novel synthetic lethal (SL) therapeutic targets in cancer. The research focuses on validating the PELOTA (PELO) and HBS1-like translational GTPase (HBS1L) ribosome rescue complex as a synthetic lethal target for two distinct cancer subtypes: biallelic chromosome 9p21.3 deletion (9p21.3-/-) and microsatellite instability-high (MSI-H) cancers. The project builds on prior discoveries published in Nature (2019, 2020, and 2025) demonstrating that both molecular subtypes independently destabilize the super killer complex (SKIC), rendering cells dependent on PELO for survival. This dependency occurs in approximately 5% of all cancers, representing a substantial and underserved patient population with urgent therapeutic needs. Under Aim 1 of the project, Columbia researchers will validate the hypothesis that SKIC deficiency (DSKIC) functions as a cancer-lineage agnostic predictor of PELO-HBS1L dependency through systematic evaluation of viability effects using PELO and HBS1L knockdown studies. The research aims to establish a mechanistic foundation for a novel precision oncology therapeutic class targeting these vulnerable cancer populations, with findings expected to advance both understanding of this synthetic lethal phenomenon and the development of therapeutically actionable precision medicine approaches for DSKIC-driven cancers.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $501.4k | 4/2/26 |