Project Grant R01CA299955

Award Date 5/1/25
Completion Date 4/30/30
Dollars Obligated $627K
Federal Grant Program
93.395
Assistance Type
Project Grant
Place of Performance
Michigan, USA
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This federal Project Grant award from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), aims to develop a novel intervention against colorectal cancer associated with colibactin-producing gut bacteria. The 5-year, $627,422 award to the Regents of the University of Michigan will fund research to engineer commensal E. coli bacteria to display an enzyme that can neutralize the genotoxic effects of colibactin. The research will optimize the surface display of this enzyme, evaluate the protective efficacy in human organoid models, and assess the ability of the engineered bacteria to reduce tumorigenesis in a clinically relevant colorectal cancer mouse model. This work seeks to produce a first-of-its-kind intervention against colibactin-induced colorectal cancer and advance the understanding of the link between microbial products and cancer development.

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