Project Grant R01CA299449
- Federal Project Grant Award Summary Award Details: The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded $150,104 to The University of Texas MD Anderson Cancer Center on December 18, 2025, with a completion date of June 2, 2028. Products and Services: This project grant supports the development of computational tools and analytical approaches to map the evolutionary trajectories of complex genome rearrangements in cancer. The award funds two...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded The University of Texas MD Anderson Cancer Center a $1,129,390 Project Grant under the Cancer Biology Research program (CFDA 93.396) effective June 10, 2025, with completion targeted for May 31, 2030. This fundamental research initiative focuses on investigating acyl-CoA binding protein (ACBP) as a newly identified driver of breast cancer bone metastasis and exploring its therapeutic vulnerability. The research leverages...
- Federal Grant Award Summary The National Cancer Institute awarded The University of Texas MD Anderson Cancer Center a $420,400 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025, through July 31, 2027. This award supports exploratory studies investigating cellular resistance mechanisms to second-generation MTA-cooperative PRMT5 inhibitors (MTA:PRMT5I) in MTAP-loss tumors. The research addresses a critical clinical challenge whereby 40-60% of patients...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $370,173 Project Grant from the National Cancer Institute (NCI) under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded September 9, 2025, with completion targeted for August 31, 2030. This award funds research to develop and validate advanced methodologies for measuring and characterizing genetic interactions in cancer cells, with particular emphasis on identifying synthetic...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a $2.64M project grant under the Cancer Biology Research program (CFDA 93.396) to The University of Texas MD Anderson Cancer Center for a four-year study (August 1, 2025 – July 31, 2029) investigating age-related increases in omental metastatic competence in ovarian cancer patients. The research will identify mechanisms by which aging enhances the omentum's susceptibility to cancer cell colonization and develop...
- Federal Grant Award Summary The University of Texas MD Anderson Cancer Center received a $163,500 Project Grant award from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395) on July 2, 2025, with completion scheduled for June 30, 2027. This award supports research aimed at developing targeted therapeutic approaches for E-cadherin-negative diffuse-type gastric adenocarcinoma (DGAC), an aggressive cancer subtype with increasing incidence rates and poor...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $680,129 Project Grant to The University of Texas MD Anderson Cancer Center for the Cancer Treatment Research program (CFDA 93.395) beginning April 1, 2026 and concluding March 31, 2031. This award funds the development of drug-loaded degradable biopolymeric scaffolds designed to augment preoperative liver growth in hepatic surgery patients. The project addresses critical clinical needs by developing a controlled...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $421,685 Project Grant under the Cancer Biology Research program (CFDA 93.396) to The University of Texas MD Anderson Cancer Center, effective August 1, 2025, through July 31, 2027. This award supports pan-cancer analysis of convergent immunoglobulins from tumor-infiltrating B cells (TIL-B), with the primary deliverable being the identification and characterization of shared B cell receptors (BCR) and antibodies across...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded $131,933 to The University of Texas MD Anderson Cancer Center under the Cancer Research Manpower program (CFDA 93.398) for the project "Spatial and Functional Profiling Tumor Evolution Trajectories and Microenvironment Interactions of VHL Driven Renal Cancers." The award, effective May 1, 2026 through April 30, 2028, supports research aimed at addressing treatment resistance in clear cell renal cell...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded a $473,372 Project Grant (CFDA 93.396 - Cancer Biology Research) to The University of Texas MD Anderson Cancer Center on April 8, 2026, through March 31, 2031. This award funds fundamental research investigating proline transfer RNA (tRNA) biogenesis as an oncogenic driver and potential therapeutic target in T cell acute lymphoblastic leukemia (T-ALL). The research addresses a critical knowledge gap regarding mechanisms...
The National Cancer Institute awarded a $688,073 Project Grant to The University of Texas MD Anderson Cancer Center beginning June 1, 2026, through May 31, 2031, under the Cancer Biology Research program (CFDA 93.396). Principal Investigator Dr. Peter Van Loo will develop and advance computational approaches to reconstruct the evolutionary history of cancer metastases, with particular focus on understanding genetic makeup and evolutionary dynamics that drive metastatic disease progression. The research builds upon the Van Loo laboratory's established expertise in "molecular archeology of cancer"—leveraging DNA sequencing data to infer tumor evolutionary history—and extends these methodologies to address the unique genomic characteristics of metastatic cancers, which demonstrate higher frequencies of aneuploidy and whole-genome duplication compared to primary tumors. The deliverables under this award include the development of novel computational methods and tools to elucidate evolutionary patterns in metastatic cancer, building upon the laboratory's recently developed chromosomal gain timing approach (GRITIC) designed specifically for timing complex copy number gains. By advancing understanding of how cancer metastases evolve and establishing methodologies to infer their evolutionary history, this research aims to contribute foundational knowledge that could support future interventions to prevent a significant proportion of cancer-related deaths.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $688.1k | 5/5/26 |