Project Grant K99CA307136
- Federal Project Grant Award Summary Award Details: The National Cancer Institute (NCI), under the Cancer Research Manpower program (CFDA 93.398), awarded $150,104 to The University of Texas MD Anderson Cancer Center on December 18, 2025, with a completion date of June 2, 2028. Products and Services: This project grant supports the development of computational tools and analytical approaches to map the evolutionary trajectories of complex genome rearrangements in cancer. The award funds two...
- Federal Grant Award Summary The National Cancer Institute awarded The University of Texas MD Anderson Cancer Center a $420,400 Project Grant under the Cancer Treatment Research program (CFDA 93.395) effective August 1, 2025, through July 31, 2027. This award supports exploratory studies investigating cellular resistance mechanisms to second-generation MTA-cooperative PRMT5 inhibitors (MTA:PRMT5I) in MTAP-loss tumors. The research addresses a critical clinical challenge whereby 40-60% of patients...
- Federal Grant Award Summary The University of Texas MD Anderson Cancer Center received a $449,625 Project Grant from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), awarded on September 15, 2025, with completion targeted for July 31, 2030. This award funds the development of novel statistical methods to delineate spatial and temporal patterns of cell-cell interactions (CCIs) in spatial transcriptomics (ST)...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $192,240 Project Grant from the National Cancer Institute (NCI) under the Cancer Research Manpower program (CFDA 93.398), effective August 1, 2025, through July 31, 2030. This award funds research to decode mosaic chromosomal alterations (MCAs) in lymphoid malignancy risk and outcomes. The project delivers comprehensive scientific investigation into somatic megabase-scale alterations detectable...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $421,685 project grant from the National Cancer Institute under the Cancer Treatment Research program (CFDA 93.395), awarded August 1, 2025, with a completion date of July 31, 2027. This award supports research investigating the LIFR-LCN2 pathway as a novel mechanism of immune suppression in hepatocellular carcinoma (HCC). The research aims to elucidate how loss of LIFR upregulates LCN2, leading to...
- Federal Grant Award Summary The University of Texas MD Anderson Cancer Center received a $680,129 Project Grant from the National Cancer Institute (NCI) under the Cancer Treatment Research program (CFDA 93.395), effective April 1, 2026 through March 31, 2031. This award supports the development of drug-loaded degradable biopolymeric scaffolds designed to augment preoperative liver growth in cancer patients undergoing surgical resection. The research addresses critical clinical challenges...
- Federal Project Grant Award Summary The University of Texas MD Anderson Cancer Center received a $510,671 Project Grant from the National Cancer Institute under the Cancer Cause and Prevention Research program (CFDA 93.393), awarded May 1, 2026, with a completion date of April 30, 2031. This award funds research into the functional characterization of lineage plasticity in cholangiocarcinoma (CCA), a highly aggressive bile duct cancer. The project will deliver a comprehensive functional...
- Federal Project Grant Award Summary The National Cancer Institute (NCI) awarded a Project Grant of $616,715 to The University of Texas MD Anderson Cancer Center, with an award date of August 11, 2025 and completion date of July 31, 2030. This award supports research under the Cancer Treatment Research program (CFDA 93.395), which develops and evaluates improved methods of cancer treatment through fundamental and applied laboratory and clinical research. The funded research centers on the...
- Federal Grant Award Summary The National Cancer Institute (NCI) awarded MD Anderson Cancer Center a $2.46 million project grant under the Cancer Treatment Research program (CFDA 93.395) effective August 18, 2025, through July 31, 2030. The INHANCE (Imaging Innovation for Head and Neck Cancer Evaluation & Treatment Delivery) initiative develops advanced imaging and computational image analysis methodologies to predict, detect, prevent, and manage therapy-related normal tissue injury in head...
- Federal Project Grant Award Summary The National Cancer Institute awarded a $421,685 Project Grant under the Cancer Biology Research program (CFDA 93.396) to The University of Texas MD Anderson Cancer Center, effective August 1, 2025, through July 31, 2027. This award supports pan-cancer analysis of convergent immunoglobulins from tumor-infiltrating B cells (TIL-B), with the primary deliverable being the identification and characterization of shared B cell receptors (BCR) and antibodies across...
The National Cancer Institute (NCI) awarded a $131,933 Project Grant to The University of Texas MD Anderson Cancer Center under the Cancer Research Manpower program (CFDA 93.398) for the period May 1, 2026 through April 30, 2028. This award supports research focused on spatial and functional profiling of tumor evolution trajectories and microenvironment interactions in VHL-driven renal cancers, specifically clear cell renal cell carcinoma (CCRC). The research will employ spatially resolved transcriptomics, genomic engineering, and multi-omics methodologies to create a comprehensive spatial atlas of treatment-resistant CCRC and identify molecular drivers of therapy resistance across sub-clonal populations. The project will deliver cross-species spatially resolved multi-omics data mapping tumor evolution trajectories and characterizing interactions between cancer cells, immune components, and stromal elements. Utilizing advanced self-barcoding technology and spatial multi-omics integration, the research will generate sub-clonal transcriptomic fingerprints to address critical knowledge gaps regarding intra-tumoral heterogeneity and its impact on therapy resistance in one of the most chemotherapy-resistant cancer types. As a leading NCI-designated Comprehensive Cancer Center, MD Anderson's multidisciplinary research teams will leverage institutional expertise in translational oncology and genomic characterization to advance understanding of VHL-driven renal cancer biology and treatment mechanisms.Federal Project Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $131.9k | 4/10/26 |