Project Grant R01CA302874

Award Date 7/1/25
Completion Date 6/30/30
Dollars Obligated $650K
Federal Grant Program
93.394
Assistance Type
Project Grant
Place of Performance
California, USA
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This $650,450 Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) supports the development of a novel TCR-engineered CD4+ T cell therapy for the treatment of lung cancer. The funded research project, led by the University of Southern California, aims to:

  1. Determine the mechanisms by which the proprietary "MIIC4 TCRM50A-STEM2 T cells" (or IMT-423) eliminate lung cancer cells.
  2. Produce GMP-grade master cell bank and viral particles, and scale up the manufacturing process for the TCRM50A-STEM2 T cell therapy.
  3. Assess the biodistribution and toxicity of the TCRM50A-STEM2 T cells and prepare an Investigational New Drug (IND) application for FDA review.

The overall goal is to advance the development of this TCR-T cell immunotherapy for lung cancer patients, and potentially expand its application to other cancers expressing the CT83 antigen. The project builds upon previous research demonstrating the robust anti-tumor activity of the MIIC4 TCRM50A-STEM2 T cells in preclinical models.

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