Project Grant R01CA298306
Award Date
7/1/25
Completion Date
6/30/30
Dollars Obligated
$510K
Federal Agency
National Cancer Institute
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Maryland, USA
Similar Awards
The National Cancer Institute (NCI) awarded a $954,000 Project Grant (CFDA 93.396 - Cancer Biology Research) to the University of Pittsburgh to investigate how aging promotes the growth of glioblastoma, one of the most lethal forms of cancer. The research aims to leverage insights from the biology of neural stem cells and the molecular circuitry of cancer stem cells to understand how aging creates a tumor microenvironment that supports the survival and proliferation of glioblastoma. The...
This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower) provides $123,182 to the H. Lee Moffitt Cancer Center and Research Institute Hospital, Inc. in Tampa, Florida. The funding supports research to understand the mechanisms by which dormant breast cancer cells communicate with their environment, including how obesity can reawaken these dormant cells and lead to metastatic relapse. Key focus areas include defining the regulatory network controlling...
This Project Grant award from the National Cancer Institute (NCI), under the federal Cancer Biology Research program (CFDA 93.396), provides $442,236 to the University of Alabama at Birmingham (UAB) from January 1, 2025 through December 31, 2029. The funding supports research to uncover a novel melanoma metastasis pathway driven by the YTHDF1 RNA-binding protein, and to evaluate therapeutic targeting of the IMPDH1 and TRKB/BDNF pathways that mediate this process. The research utilizes...
The National Cancer Institute (NCI) awarded a $852,164 Project Grant (CFDA 93.396 - Cancer Biology Research) to The Johns Hopkins University to study the impact of the plantar skin microenvironment on acral melanoma (AM) metastasis and drug resistance. The research aims to: Mechanistically define how matrix stiffness of the plantar skin affects AM cell metabolism, particularly lysosomal catabolism. This will involve in vitro and in vivo studies using live cell reporters, protein markers, and RNA...
The National Cancer Institute (NCI) awarded a $547,945 Project Grant under CFDA 93.396 (Cancer Biology Research) to The Johns Hopkins University to conduct research on the pathogenesis of immune checkpoint inhibitor-induced myocarditis. The project aims to investigate how biological factors such as prior cardiac injury, age, and sex modulate the risk of this adverse event, which occurs in 1-2% of cancer patients receiving immune checkpoint inhibitor therapy but can be fatal in up to 50% of...
The National Cancer Institute (NCI) awarded a $162,080 Project Grant under the Cancer Research Manpower (CFDA 93.398) federal grant program to The Johns Hopkins University. The grant supports a study to visualize B cell infiltration and aggregation within the tumor microenvironment. Specifically, the study uses transgenic mouse models and intravital microscopy to investigate how high endothelial venules facilitate B cell entry into tumors and the formation of tertiary lymphoid structures,...
This Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) provides $204,474 to The Regents of the University of Colorado to conduct research aimed at defining the relationship between cell quiescence and senescence. The project will use advanced microscopy techniques and RNA sequencing to study the molecular mechanisms that mediate the transition from a reversible quiescent state to permanent cell cycle arrest, or senescence. The research...
This $369,868 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to investigate the functional role of mitochondrial transfer from nerves to breast cancer cells, and how this process impacts cancer metastasis and the generation of cancer stem cells. The project aims to use innovative lineage-tracing techniques to quantify the contribution of nerve-to-cancer mitochondrial transfer to the breast cancer metastasis cascade, and evaluate...
This Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) provides $198,103 to New York University School of Medicine to conduct research on melanoma bone metastasis. The goal is to better understand how melanoma cells infiltrate the bone microenvironment and interact with the immune system, in order to develop improved treatments for melanoma patients with bone metastases. The 2-year project will utilize preclinical murine models to examine the role...
The National Cancer Institute (NCI), under the Federal Grant Program "Cancer Research Manpower" (CFDA 93.398), awarded a Project Grant in the amount of $145,336 to the Sloan-Kettering Institute for Cancer Research located in New York. The grant, titled "Metabolically Reprogramming Hepatic Macrophages to Conquer Immune Desert Tumors," will fund research focused on reprogramming hepatic macrophages to overcome the "immune-desert" phenotype of B-catenin-driven...