This National Cancer Institute (NCI) R21 Project Grant award to New York University (NYU) School of Medicine is funding research to investigate the role of the immune microenvironment in melanoma bone metastasis. The $198,103 grant, awarded on June 20, 2025, supports the development of preclinical murine models that recapitulate human melanoma bone metastasis. The research aims to define the mechanisms melanoma cells use to colonize the skeleton and modify the bone microenvironment, with a focus on examining the interplay between tumor, skeletal, and immune cells. The project is part of the NCI's Cancer Treatment Research program (CFDA 93.395), which supports innovative research to advance cancer prevention, diagnosis, and treatment. The successful outcomes of this work are expected to improve understanding of melanoma growth in bone and pave the way for better treatments for bone metastatic disease.
Generated 3/4/25, 7:38 AM