Project Grant R01CA296643

Award Date 1/1/25
Completion Date 12/31/29
Dollars Obligated $536K
Federal Grant Program
93.393
Assistance Type
Project Grant
Place of Performance
Gainesville, FL 32611, USA
Similar Awards
The National Cancer Institute awarded a $159,183 Project Grant under the Cancer Research Manpower (CFDA 93.398) federal grant program to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The project, titled "Investigating the Role of Diet and ACSS2 in Metabolic and Epigenetic Regulation of Colorectal Cancer," aims to examine how dietary factors like fructose and fiber interact with the ACSS2 enzyme to influence...
This Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) to the University of Florida supports research to characterize a bacterial-derived small molecule, BAC429, and explore its potential to enhance the efficacy of anti-PD-1 cancer immunotherapy. The $540,288 award, effective from May 1, 2025 to April 30, 2030, aims to: 1) define the functional impact of BAC429 on non-small cell lung cancer, 2) establish the relationship between diet and BAC429...
This Project Grant award from the National Cancer Institute (CFDA 93.395 Cancer Treatment Research) aims to develop a first-of-its-kind intervention against colorectal cancer associated with colibactin-producing bacteria. The $627,422 award to the Regents of the University of Michigan will fund research to engineer E. coli bacteria to display an enzyme that can neutralize the genotoxin colibactin, thereby preventing DNA damage and tumorigenesis. The 5-year project will optimize the surface...
This Project Grant award from the National Cancer Institute (NCI), under the Cancer Treatment Research program (CFDA 93.395), provides $606,839 to Weill Medical College of Cornell University to study the role of microbiota amino acid metabolism in cancer. The project aims to identify gut microbes and their genes that deplete intestinal amino acids, and evaluate how they affect the tumor microenvironment and cancer progression. The 5-year project will combine bioinformatics, metabolomics,...
This Cooperative Agreement award from the National Cancer Institute (CFDA 93.396 Cancer Biology Research) provides $624,518 in funding to the University of South Florida to conduct research on the role of arachidonic acid metabolism in modulating the tumor immune microenvironment for colorectal cancer. The project aims to: 1) analyze arachidonic acid pathway lipid mediators in a large reference set of clinically-curated colorectal cancer samples to understand their relationship to immune...
This federal Project Grant award from the National Cancer Institute (CFDA 93.393 - Cancer Cause and Prevention Research) provides $456,764 to the University of Chicago to study differences in bile acid metabolism and colonic responses between African Americans and non-Hispanic whites, and their potential connection to colorectal cancer disparities. The key objectives of this 2-year research project are to: 1) compare serum bile acid composition between the two populations, 2) perform...
The National Cancer Institute (NCI), part of the National Institutes of Health (NIH), awarded a $406,611 Project Grant (CFDA 93.395 - Cancer Treatment Research) to the University of Texas Health Science Center at Houston (UTHealth). The grant, titled "The Role and Therapeutic Targeting of GPR56 in Colorectal Cancer," aims to investigate the function and signaling mechanisms of the GPR56 protein in colorectal cancer progression and therapy resistance. Key objectives include:...
This Project Grant award of $400,890.00 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) aims to profile patient-specific tumor-microbiome interactions and conduct quantitative molecular analyses to elucidate microbiome-mediated modulation of immune checkpoint molecules in mismatch repair-proficient, microsatellite-stable colorectal tumors. The award, granted to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, will utilize...
This Project Grant award from the National Cancer Institute (CFDA 93.394 - Cancer Detection and Diagnosis Research) provides $221,456.00 to the Regents of the University of Minnesota to develop and optimize a novel approach for enriching microbes from clinical cancer samples. The goal is to enable deep metaproteomic analysis to better understand how non-host microorganisms influence carcinogenesis and cancer treatment. The 3-year project will pursue two specific aims: 1) optimizing and...
This Project Grant award of $688,092 from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at Yale University to investigate the role and regulation of asparagine in colorectal cancer. The research aims to: Determine if the asparagine synthetase (ASNS) enzyme and G-protein coupled estrogen receptor 1 (GPER1) act as sex-specific prognostic biomarkers in advanced stage colorectal cancer patients. This will include analyzing patient stool samples to identify...

This Project Grant award from the National Cancer Institute (CFDA 93.393 Cancer Cause and Prevention Research) provides $536,489 to the University of Florida to investigate the interaction between dietary taurine and gut microbiota sulfur metabolism in the development of colorectal cancer.

The key research objectives are to: 1) Determine how dietary taurine and the presence of the bacteria Bilophila wadsworthia impact intestinal inflammation and tumor development, 2) Elucidate the mechanism by which the bacterial metabolite hydrogen sulfide (H2S) produced from taurine promotes neoplastic effects, and 3) Evaluate the impact of energy drink consumption on microbiota function in a healthy young adult cohort. The project aims to provide insights for preventing intestinal inflammation and colorectal cancer through modulating taurine intake or bacterial metabolic activity. The award period is from January 1, 2025 to December 31, 2029.

Generated 7/15/25, 3:16 AM