Project Grant R01CA294365

Award Date 2/1/25
Completion Date 1/31/30
Dollars Obligated $658K
Federal Grant Program
93.396
Assistance Type
Project Grant
Place of Performance
Houston, TX 77204, USA
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This $658,223 Project Grant awarded by the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research at the University of Houston to investigate the role of the TAK1 signaling protein in the development and growth of rhabdomyosarcoma (RMS), a type of malignant sarcoma. The key products and services to be delivered under this 5-year award include:

  1. Elucidating the molecular mechanisms by which aberrant TAK1 activation drives RMS tumorigenesis and inhibits myogenic differentiation (Aim 1).

  2. Examining the signaling pathways through which TAK1 promotes cancer stem cell enrichment and suppresses RMS cell differentiation (Aim 2).

  3. Evaluating the therapeutic potential of TAK1 inhibition in preclinical RMS xenograft and patient-derived xenograft models (Aim 3).

The overarching goal is to identify TAK1 as a novel therapeutic target to treat RMS by both reducing tumor growth and promoting differentiation of RMS cells. This research builds upon the awardee's preliminary studies demonstrating the critical role of TAK1 in RMS progression and its potential as a therapeutic approach.

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