The National Cancer Institute (NCI) awarded a 5-year, $491,826 Project Grant (CFDA 93.396 - Cancer Biology Research) to The University of Texas Southwestern Medical Center (UT Southwestern) in Dallas, Texas. This grant supports research into the role of Testis-Specific Serine Kinase 6 (TSSK6) in colorectal cancer. The project aims to comprehensively investigate how TSSK6, a protein normally restricted to testicular tissue, promotes tumor growth, metastasis, and chemotherapy resistance when aberrantly expressed in colorectal cancer. The research will examine the signaling pathways through which TSSK6 enhances focal adhesion formation and survival signaling in cancer cells. The findings are expected to reveal new functional biomarkers and preclinical models to support the development of TSSK6 as a therapeutic target for colorectal cancer.
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