The National Institutes of Health (NIH), through the Cancer Biology Research (CFDA 93.396) program, awarded a $618,928 Project Grant to the University of California, Berkeley to investigate the role of regulatory T cells (Tregs) in suppressing antitumor immune responses. The overarching objective is to decipher whether blocking Treg function within tumors is sufficient for tumor control and to uncover the mechanisms of intratumoral Treg immunosuppression. The research will examine how Tregs function within tumors to reduce dendritic cell antigen uptake, thereby limiting T cell priming in the tumor-draining lymph nodes. The project aims to identify new genetic targets to prevent Treg suppression of dendritic cell priming of antitumor T cells without inducing autoimmune toxicity. The award period runs from June 9, 2025 to May 31, 2030.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $618.9k | 6/9/25 |